Evidence map›Paper›PMID 40560632›Full record

ArticleeLife2025

Atoh1 is required for the formation of lateral line electroreceptors and hair cells, whereas FoxG1 represses an electrosensory fate.

Martin Minařík, Alexander S Campbell, Roman Franěk, Michaela Vazačová, Miloš Havelka, David Gela, Martin Pšenička, Clare V H Baker

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Martin MinaříkDepartment of Physiology, Development & Neuroscience, University of Cambridge, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0001-6660-0031
Alexander S CampbellDepartment of Physiology, Development & Neuroscience, University of Cambridge, Cambridge, United Kingdom.ORCID https://orcid.org/0009-0003-1539-214X
Roman FraněkFaculty of Fisheries and Protection of Waters, Research Institute of Fish Culture and Hydrobiology, University of South Bohemia in České Budějovice, Vodňany, Czech Republic.ORCID https://orcid.org/0000-0002-3464-1872
Michaela VazačováFaculty of Fisheries and Protection of Waters, Research Institute of Fish Culture and Hydrobiology, University of South Bohemia in České Budějovice, Vodňany, Czech Republic.
Miloš HavelkaFaculty of Fisheries and Protection of Waters, Research Institute of Fish Culture and Hydrobiology, University of South Bohemia in České Budějovice, Vodňany, Czech Republic.ORCID https://orcid.org/0000-0003-3574-6243
David GelaFaculty of Fisheries and Protection of Waters, Research Institute of Fish Culture and Hydrobiology, University of South Bohemia in České Budějovice, Vodňany, Czech Republic.
Martin PšeničkaFaculty of Fisheries and Protection of Waters, Research Institute of Fish Culture and Hydrobiology, University of South Bohemia in České Budějovice, Vodňany, Czech Republic.ORCID https://orcid.org/0000-0002-3808-7856
Clare V H BakerDepartment of Physiology, Development & Neuroscience, University of Cambridge, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0002-4434-3107

Funding

Anatomical Society Research StudentshipBiotechnology and Biological Sciences Research Council BB/P001947/1Cambridge Philosophical Society Research StudentshipCzech Science Foundation Project 22-31141JIsaac Newton Trust Grant 20.07(c)Isaac Newton Trust Grant 20.07 (c)Ministry of Education, Youth and Sports of the Czech Republic Biodiversity CZ.02.1.01/0.0/0.0/16_025/0007370Ministry of Education, Youth and Sports of the Czech Republic CENAKVA LM2018099Ministry of Education, Youth and Sports of the Czech Republic Projects CENAKVA (LM2018099) and Biodiversity (CZ.02.1.01/0.0/0.0/16_025/0007370)
6 · The paper itself

Abstract

In electroreceptive jawed fishes and amphibians, individual lateral line placodes form lines of neuromasts on the head containing mechanosensory hair cells, flanked by fields of ampullary organs containing electroreceptors-modified hair cells that respond to weak electric fields. Extensively shared gene expression between neuromasts and ampullary organs suggests that conserved molecular mechanisms are involved in their development, but a few transcription factor genes are restricted either to the developing electrosensory or mechanosensory lateral line. Here, we used CRISPR/Cas9-mediated mutagenesis in G0-injected sterlet embryos (

Indexed as

Basic Helix-Loop-Helix ProteinsFishesFish ProteinsForkhead Transcription FactorsHair Cells, AuditoryLateral Line SystemAnimalsCell DifferentiationGene Expression Regulation, DevelopmentalBasic Helix-Loop-Helix ProteinsFish ProteinsForkhead Transcription FactorsAcipenser ruthenusampullary organsAtoh1developmental biologyFoxg1lateral lineneuromastssterlet sturgeon

Identifiers

PMID40560632
PMCPMC12456953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.