Evidence map›Paper›PMID 40560620›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Global kinetic model of lipid-induced

Alisdair Stevenson, Roxine Staats, Alexander J Dear, David Voderholzer, Jesper E Dreier, Georg Meisl, Raphael Guido, Tuomas P J Knowles, Céline Galvagnion, Alexander K Buell and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Global kinetic model of lipid-inducedProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alisdair StevensonDepartment of Biology, Institute of Biochemistry, ETH Zurich, Zurich 8093, Switzerland.ORCID 0009-0000-2105-6669
Roxine StaatsYusuf Hamied Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge CB2 1EW, United Kingdom.
Alexander J DearDepartment of Biology, Institute of Biochemistry, ETH Zurich, Zurich 8093, Switzerland.
David VoderholzerDepartment of Biology, Institute of Biochemistry, ETH Zurich, Zurich 8093, Switzerland.ORCID 0009-0001-2806-2022
Jesper E DreierDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen 2100, Denmark.ORCID 0000-0002-0740-1750
Georg MeislYusuf Hamied Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge CB2 1EW, United Kingdom.ORCID 0000-0002-6562-7715
Raphael GuidoDepartment of Biology, Institute of Biochemistry, ETH Zurich, Zurich 8093, Switzerland.ORCID 0009-0002-8321-521X
Tuomas P J KnowlesYusuf Hamied Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge CB2 1EW, United Kingdom.ORCID 0000-0002-7879-0140
Céline GalvagnionDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen 2100, Denmark.
Alexander K BuellDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby 2800, Denmark.ORCID 0000-0003-1161-3622
Michele VendruscoloYusuf Hamied Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge CB2 1EW, United Kingdom.ORCID 0000-0002-3616-1610
Thomas C T MichaelsDepartment of Biology, Institute of Biochemistry, ETH Zurich, Zurich 8093, Switzerland.

Funding

Lundbeck Foundation (Lundbeckfonden) R314-2018-349Novo Nordisk Foundation NNF17SA0028392Novo Nordisk Foundation NNF20OC0059417Swiss National Science Foundation SNS 219703UK Research and Innovation (UKRI) 1005943UK Research and Innovation (UKRI) 1006110
6 · The paper itself

Abstract

The aggregation of

Indexed as

alpha-SynucleinLipidsProtein AggregatesAmyloidHumansKineticsProtein Aggregation, Pathologicalalpha-SynucleinAmyloidLipidsProtein Aggregatesaggregation inhibitorslipid-induced amyloid aggregationParkinson’s disease

Identifiers

PMID40560620
PMCPMC12232617

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.