Evidence map›Paper›PMID 40560571›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2025

Serotonin neurons are necessary for tonic sodium intake inhibition.

Silvia Gasparini, Gordon F Buchanan, Joel C Geerling

Abstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Silvia GaspariniDepartment of Neurology, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0002-5487-7081
Gordon F BuchananDepartment of Neurology, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0003-2371-4455
Joel C GeerlingDepartment of Neurology, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0001-9956-4006

Funding

Brainstem cold-defense circuitryR01NS130038 · NINDS · UNIVERSITY OF IOWA · PI Joel Charles Geerling · 2023 to 2026
$2.2M
PB-FI connectivity and arousalK08NS099425 · NINDS · UNIVERSITY OF IOWA · PI GEERLING, JOEL CHARLES · 2017 to 2021
$961k
HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS099425HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS130038NINDS NIH HHS K08 NS099425NINDS NIH HHS R01 NS130038Roy J. Carver Charitable Trust (RJCCT) Iowa Neuroscience Institute Early-stage Research Program of Excellence awardUniversity of Iowa (UI) Aging Mind and Brain Initiative (AMBI)University of Iowa (UI) Department of Neurology laboratory startup funds
6 · The paper itself

Abstract

Sodium appetite is a motivated behavior that occurs in response to sodium deprivation. Various neurotransmitters, including serotonin, are thought to regulate sodium intake. In the present study, we used genetic deletion to test whether serotonergic neurons are necessary for regulating sodium appetite. First, we confirmed that

Indexed as

AppetiteSerotonergic NeuronsSodium Chloride, DietaryAnimalsDrinkingFurosemideMaleMiceMice, Inbred C57BLMice, KnockoutSerotoninSodiumThirstWater DeprivationFurosemideSerotoninSodiumSodium Chloride, DietaryLmx1bPet1serotoninserotoninergicsodium appetite

Identifiers

PMID40560571
PMCPMC12311553

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.