ArticleAmerican journal of epidemiology2025
Sociodemographic, health-related, and clinical characteristics and their associations with mortality among All of Us participants compared with the United States general population.
Article in American journal of epidemiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Comparative analysis of fatigue and mental health in sexual and gender minority cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Assessing the generalizability of prevalence estimates from the All of Us Research Program.American journal of epidemiology · 2026Article
- Article
- Associations of unmet dental care needs due to cost with incident cardiovascular disease and dementia: a prospective study in the All of Us cohort.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- GLP-1 Receptor Agonist Prescription Patterns in themedRxiv : the preprint server for health sciences · 2026Article
- Prevalence of Risk Factors and Established Cardiovascular Disease Among All of Us Participants: Benchmarking Against National Estimates.medRxiv : the preprint server for health sciences · 2025Article
- Detection Bias in EHR-Based Research on Clinical Exposures and Dementia.JAMA network open · 2025Article
- Memantine, acetylcholinesterase inhibitors, and quality-of-care outcomes among patients with cognitive impairment: an emulated trial design.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The large and diverse All of Us Research Program offers tremendous opportunities for health research. However, results may not be generalizable to the US population due to the program's targeted recruitment efforts. We compared All of Us participants to those from the nationally representative continuous 1999-2018 National Health and Nutrition Examination Survey (NHANES) with respect to overall mortality rates; the distribution of sociodemographic, health-related, and clinical characteristics; the association of each characteristic with mortality estimated using Cox proportional hazards models; and population attributable fractions (PAFs) for each characteristic and mortality. All of Us participants were older, less likely to be non-Hispanic White, had more years of education, and had a higher prevalence of major chronic conditions than NHANES. Mortality rates were generally lower for All of Us participants, especially at older ages. The direction of associations in All of Us and NHANES matched for almost all comparisons but differed in magnitude for some conditions, primarily clinical diagnoses. PAFs were generally higher in All of Us. Predictors of mortality in All of Us do not consistently generalize to the US population. Analytical approaches are needed to address nonrepresentativeness and mitigate potential biases associated with the selection into the All of Us cohort.
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Registered trials
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