ArticleMolecular neurobiology2025
Impaired Synaptic Plasticity Mediated by Decreased GLUT1 in Hippocampal Astrocytes is Involved in Postoperative Cognitive Dysfunction in Elderly Mice.
Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Regulatory role of GLUT1 in lead-induced neurotoxicity and the neuroprotective effect ofiScience · 2026Article
- Esketamine Alleviates Postoperative Cognitive Dysfunction via Rock2/Add1 Signaling Pathway in Aged Mice.Neurochemical research · 2026Article
- The emerging role of ubiquitin-proteasome system dysfunction in the pathogenesis of perioperative neurocognitive disorders: a narrative review.Frontiers in behavioral neuroscience · 2026Review
- Targeting the astrocytic metabolic cascade in Alzheimer's disease: mechanisms, challenges and opportunities.Frontiers in aging neuroscience · 2026Review
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Authors and funding
15 authors.
Funding
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Abstract
Postoperative cognitive dysfunction (POCD) is a common post-anesthesia complication in elderly patients characterized by impaired learning and memory function, with largely unclear neural mechanisms. This study aims to examine how Glucose transporter1 (GLUT1) affects the cognitive function changes in elderly mice with POCD by focusing on hippocampal astrocytes. GLUT1 on hippocampal astrocytes is crucial for brain glucose metabolism, and altered GLUT1 expression may affect the brain's energy supply and utilization, impacting synaptic plasticity and cognitive function. In this study, we found elderly mice developed POCD 1 day post-operation, showing reduced levels of GLUT1 expression on hippocampal astrocytes and decreased energy supply in the hippocampus. Meanwhile, the density of dendritic spines of hippocampal neurons notably decreased, resulting in impaired structural and functional plasticity. In the intervention experiment, overexpression of GLUT1 on hippocampal astrocytes alleviated the above neural dysfunction; besides, the hippocampal-dependent learning and memory impairment 1 day after anesthesia/surgery in mice were significantly improved. Briefly, we demonstrate that GLUT1 plays a crucial part in the development of POCD in elderly mice, indicating that it could be a valuable target for diagnosing and treating POCD.
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Registered trials
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