Observational studyEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2025
Risk factors for severe lower respiratory tract infection among children under 5 years of age hospitalized with respiratory syncytial virus.
Observational study in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Assessing the willingness and preference of pregnant and postpartum women regarding RSV immunization for newborns in western China: A mixed-methods study.Human vaccines & immunotherapeutics · 2026Article
- Predictive Model for Critical Illness Infection in Hospitalized Children with RSV Infection: A Retrospective Study.Diagnostics (Basel, Switzerland) · 2026Article
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Authors and funding
10 authors.
Funding
Abstract
In 2023, a resurgence of acute lower respiratory tract infections (ALRTI) linked to respiratory syncytial virus (RSV) was noted following the COVID-19 pandemic. Patients' outcomes, disease severity, and demographics all changed. This study aims to identify risk factors for severe disease and the impact of other viral co-infection on severity, which has not yet been extensively studied in China. This observational cohort study comprised cases of RSV-associated ALRTI among children younger than 5 years who were admitted to the hospital from January to December 2023. Demographic characteristics, co-infection status, and laboratory parameters were compared between severe and mild groups. Logistic regression analysis was used to identify risk factors for severe RSV-ALRTI and viral co-infection, with the corresponding 95% CI and P value. Receiver Operating Characteristic (ROC) curve was drawn to analyze the efficacy of specific risk factors. A total of 1036 cases with a median age of 16 (6, 38) months; 662 boys (63.9%) were admitted with RSV-associated ALRTI; 764 (73.7%) were younger than 3 years. The cohort suggests out-of-season epidemic of RSV. Severe disease was documented for 405 cases (39.1%), with a younger median age (10 (4, 32) and a higher proportion with a history of prematurity and low-body weight (P < 0.01). The most common co-infections were bacterial co-infection (18.9%) and co-infection with other respiratory viruses (15.5%). Age combined with neutrophil proportion, concentration of lactic dehydrogenase (LDH) and Na
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