ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2025
Detection of relevant pathogens and contaminants in blood cultures after implementation of single-sampling strategy and initial specimen diversion.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBlood culture collection with all bottles filled from a single venipuncture (single-sampling strategy, SSS) is increasingly used. More data on the effects of SSS on blood culture contamination is needed. After combined implementation of SSS and initial specimen diversion (ISDT) in our region, we evaluated the proportion of sampling events with at least four bottles, with growth of relevant pathogens and with growth of coagulase-negative staphylococci (CoNS) before and after the intervention.
methodsWe retrospectively reviewed all blood cultures collected from adults in emergency departments in our region in southern Sweden during six years before and 18 months after the intervention.
resultsAmong 117 142 sampling events included in the analysis, the proportion where at least four bottles were obtained increased from 87.6 to 92.3% (p < 0.001), while growth of relevant pathogens remained unchanged at 13.6%. In the subset of sampling events with no more than one species, there was a decrease in the proportion with CoNS in 1–2 out of 4 bottles (4.0 to 3.3%, p < 0.001), while events with CoNS in 3–4 out of 4 bottles increased (0.39 to 0.49%, p = 0.029).
conclusionWe confirm positive effects of SSS and ISDT on adequate sample volume and a net decrease in the proportion of sampling events with growth of CoNS. Conversely, we observed an increase in CoNS in multiple bottles, probably caused by contamination. This possible drawback with SSS has not been reported before and should be studied further.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.