Evidence map›Paper›PMID 40560496›Full record

ArticleAnnals of surgical oncology2026

Consensus Guideline for the Management of Peritoneal Metastases from Neuroendocrine Neoplasms.

David G Su, Leanne M Brown, Varun V Bansal, Baylee Bakkila, Seth J Concors, Kiran K Turaga, Craig Gunderson, Emily Bergsland, Jonathan R Strosberg, Thorvardur R Halfdanarson and 5 more

Abstract read
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In one paragraph

Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

David G SuYale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-8693-612X
Leanne M BrownYale School of Medicine, New Haven, CT, USA.
Varun V BansalYale School of Medicine, New Haven, CT, USA.
Baylee BakkilaYale School of Medicine, New Haven, CT, USA.
Seth J ConcorsEmory University, Atlanta, GA, USA.
Kiran K TuragaYale School of Medicine, New Haven, CT, USA. kiran.turaga@yale.edu.
Craig GundersonYale School of Medicine, New Haven, CT, USA.
Emily BergslandUniversity of California San Francisco, San Francisco, CA, USA.
Jonathan R StrosbergMoffitt Cancer Center, Tampa, FL, USA.
Thorvardur R HalfdanarsonMayo Clinic, Rochester, MN, USA.
David C MetzUniversity of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
John W KunstmanYale School of Medicine, New Haven, CT, USA.
Pamela L KunzYale School of Medicine, New Haven, CT, USA.
Alexandra GangiCedars-Sinai Medical Center, Los Angeles, CA, USA.
Peritoneal Surface Malignancies (PSM) Consortium Group

Funding

Yale Cancer Center Advanced Training Program for Physician-Scientists (YCC-ATPP)T32CA233414 · NCI · YALE UNIVERSITY · PI Eric P. Winer · 2019 to 2026
$3.2M
NCI NIH HHS T32 CA233414
6 · The paper itself

Abstract

backgroundNeuroendocrine neoplasms (NEN) with peritoneal metastases (PM) represent a complex clinical challenge due to low incidence and heterogeneous phenotypes. This manuscript describes the results of a national consensus aimed at addressing clinical management of patients with NEN-PM.

methodsAn update of the 2018 Chicago consensus guidelines was conducted using a modified Delphi technique, encompassing two rounds of voting. The levels of agreement for various pathway blocks were assessed. Key systemic therapy concepts were summarized by content experts. Supporting evidence was evaluated via a rapid literature review.

resultsOverall, the level of evidence for the management of PM in this disease was universally low. In total, 107 participants responded in the first round, with 88/107 (82%) participating in the second round. Strong consensus (> 90%) was achieved in 5/7 (71%) and 7/7 (100%) blocks in rounds I and II respectively. A multidisciplinary approach including psychosocial and wellness assessments received a strong positive recommendation. Management of NENs with PM was organized according to disease grade and symptom profiles. In grade 1 and 2 well-differentiated NENs, cytoreductive surgery (CRS) received strong support (>95%) following the management of functional syndromes (if present). For grade 3 well-differentiated NENs, systemic therapy is the primary recommendation, with surgical resection considered in select cases.

conclusionGiven limited evidence, the consensus-driven clinical pathway offers vital clinical guidance for the management on NENs with PM. The need for high-quality evidence remains critical to the field.

Indexed as

Cytoreduction Surgical ProceduresNeuroendocrine TumorsPeritoneal NeoplasmsPractice Guidelines as TopicConsensusDelphi TechniqueHumansPrognosisClinical guidelinesCytoreductive surgeryNeuroendocrine neoplasmsPeritoneal surface malignanciesPeritoneal surface neoplasms

Identifiers

PMID40560496

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.