Evidence map›Paper›PMID 40560489›Full record

ReviewMolecular diversity2026

Recent advances in pyrazolo[3,4-b]pyridine chemistry: synthesis techniques and biological activity.

Anhar Abdel-Aziem, Sawsan A Fouad

Abstract readReview
In one paragraph

Review in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Anhar Abdel-AziemChemistry Department, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, 11754, Egypt. anhar@azhar.edu.eg.ORCID http://orcid.org/0000-0002-3871-3183
Sawsan A FouadChemistry Department, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, 11754, Egypt.ORCID http://orcid.org/0000-0003-3569-8181

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, attention has been drawn to pyrazolo[3,4-b] pyridine and its derivatives due to their substantial pharmacological activities such as antidepressant, anticancer, antiviral, antifungal, antioxidant, anticoagulant, anti-Alzheimer, and antimicrobial. Besides their medicinal uses, they act as herbicides, fungicides, and are also used as agrochemicals, inhibitors for a wide range of kinases, and fibroblast growth factor receptors. Additionally, pyrazolo[3,4-b] pyridines are used in developing organic materials for different applications such as chemosensors and corrosion inhibitors for mild steel. This review aims to provide an in-depth overview of the latest advancements regarding synthetic routes, reactions, and biological importance of pyrazolo [3,4-b] pyridine during 2019-2025 which will be a useful resource for interested researchers engaged in this area. The synthetic methodologies focus on metal-catalyst, nanocatalyst, microwave-assisted synthesis, multicomponent reactions, and other green chemistry approaches. Emphasizing the significance of these scaffolds in drug discovery and medicinal chemistry, new developments and future directions in the design of innovative pyrazolo[3,4-b]pyridine-based therapies are also covered.

Indexed as

Chemistry Techniques, SyntheticPyrazolesPyridinesHumansPyrazolespyrazolo(3,4-b)pyridinePyridinesBiological activityPyrazolo[3,4-b] pyridineReactionsSynthesis

Identifiers

PMID40560489
PMCPMC13635085

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.