Evidence map›Paper›PMID 40560457›Full record

ReviewEuropean journal of pediatrics2025

Peripheral neuroblastic tumors: tumor biology and its implications for risk stratification.

Aroua Anissi Eddaibouni, Sanaa Hachimi, Nisrine Bennani Guebessi, Siham Cherkaoui, Mehdi Karkouri

Abstract readReview
PubMed Publisher
In one paragraph

Review in European journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Surgical Treatment of Adrenal Neuroblastoma in Children - A Narrative Review.International braz j urol : official journal of the Brazilian Society of Urology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aroua Anissi EddaibouniCellular and Molecular Pathology Laboratory, Faculty of Medicine and Pharmacy, University Hassan II, Casablanca, Morocco. aroua.anissi-etu@etu.univh2c.ma.ORCID http://orcid.org/0000-0002-1483-5960
Sanaa HachimiAnatomopathological Laboratory, Ibn Rochd University Hospital, Casablanca, Morocco.
Nisrine Bennani GuebessiCellular and Molecular Pathology Laboratory, Faculty of Medicine and Pharmacy, Anatomopathological Laboratory, University Hassan II, Ibn Rochd University Hospital, Casablanca, Morocco.ORCID http://orcid.org/0000-0001-5057-6567
Siham CherkaouiCellular and Molecular Pathology Laboratory, Faculty of Medicine and Pharmacy, Hematology and Pediatric Oncology Department, University Hassan II, Hospital 20 August, Casablanca, Morocco.ORCID http://orcid.org/0000-0003-4115-0374
Mehdi KarkouriCellular and Molecular Pathology Laboratory, Faculty of Medicine and Pharmacy, Anatomopathological Laboratory, University Hassan II, Ibn Rochd University Hospital, Casablanca, Morocco.ORCID http://orcid.org/0000-0002-6857-7442

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peripheral neuroblastic tumor (pNT) is a pediatric tumor that originates from the sympathetic nervous system and is the most common extracranial solid malignancy found in children. It is characterized by its clinical and biological heterogeneity. Therefore, an International Neuroblastoma Risk Group (INRG) classification system was developed to create a standardized approach for pretreatment risk stratification. This system considers several factors, including the patient's age, tumor histology, the International Neuroblastoma Risk Group Staging System (INRGSS), DNA ploidy, the presence or absence of MYCN gene amplification in tumor cells, and segmental chromosomal aberrations, particularly the 11q aberration. In this review, we summarize the biological characteristics of peripheral neuroblastic tumors. We present their histopathological features, outline the different prognostic groups, discuss various molecular markers, and emphasize the importance of the risk stratification system in optimizing treatment.

Indexed as

NeuroblastomaPeripheral Nervous System NeoplasmsChildChromosome AberrationsHumansNeoplasm StagingN-Myc Proto-Oncogene ProteinPrognosisRisk AssessmentMYCN protein, humanN-Myc Proto-Oncogene ProteinHistopathologyInternational neuroblastoma risk groupMolecular markersPeripheral neuroblastic tumor

Identifiers

PMID40560457

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.