Evidence map›Paper›PMID 40560409›Full record

ArticleEuropean journal of applied physiology2025

Detection of exercise intensity thresholds in patients with chronic heart failure based on correlation properties of heart rate variability.

Noemí Sempere-Ruiz, Agustín Manresa-Rocamora, Laura Fuertes-Kenneally, Ana Sanz-Rocher, Sabina Baladzhaeva, Vicente Climent-Payá, Manuel Moya-Ramón, José M Sarabia

Abstract read
In one paragraph

Article in European journal of applied physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Reliability and validity of the respiratory threshold method.European journal of applied physiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Noemí Sempere-RuizDepartment of Sport Sciences, Sports Research Centre, Miguel Hernández University of Elche, 03202, Elche, Spain.ORCID http://orcid.org/0000-0002-1271-7194
Agustín Manresa-RocamoraDepartment of Sport Sciences, Sports Research Centre, Miguel Hernández University of Elche, 03202, Elche, Spain.ORCID http://orcid.org/0000-0002-1399-2411
Laura Fuertes-KenneallyDepartment of Sport Sciences, Sports Research Centre, Miguel Hernández University of Elche, 03202, Elche, Spain.ORCID http://orcid.org/0000-0003-1361-8806
Ana Sanz-RocherDepartment of Sport Sciences, Sports Research Centre, Miguel Hernández University of Elche, 03202, Elche, Spain.ORCID http://orcid.org/0009-0007-1476-9776
Sabina BaladzhaevaDepartment of Sport Sciences, Sports Research Centre, Miguel Hernández University of Elche, 03202, Elche, Spain.ORCID http://orcid.org/0009-0009-8730-5600
Vicente Climent-PayáInstitute for Health and Biomedical Research of Alicante (ISABIAL), 03010, Alicante, Spain.ORCID http://orcid.org/0000-0001-7362-1922
Manuel Moya-RamónDepartment of Sport Sciences, Sports Research Centre, Miguel Hernández University of Elche, 03202, Elche, Spain.ORCID http://orcid.org/0000-0002-2291-5899
José M SarabiaDepartment of Sport Sciences, Sports Research Centre, Miguel Hernández University of Elche, 03202, Elche, Spain. jsarabia@umh.es.ORCID http://orcid.org/0000-0002-1917-6634

Funding

Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital, Generalitat Valenciana 2019-107721RB-I00Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital, Generalitat Valenciana CIGE/ 2021/147Ministerio de Educación, Cultura y Deporte FPU21/00635
6 · The paper itself

Abstract

purposeThis study aimed to assess the agreement between ventilatory thresholds (VT1 and VT2), and heart rate variability (HRV) thresholds (HRVT1 and HRVT2) based on the alpha 1 index of detrended fluctuation analysis (DFA a1) in patients with chronic heart failure (CHF). Validating HRV-based thresholds could provide a cost-effective alternative for individualised exercise intensity prescription, improving safety and efficacy in exercise-based cardiac rehabilitation (CR) programmes.

methodsTwenty CHF patients (13 males, 7 females) performed a cardiopulmonary exercise test (CPET) on a cycle ergometer. Ventilatory thresholds were identified using a mixed method, while HRV thresholds were determined at DFA a1 values of 0.75 (HRVT1) and 0.5 (HRVT2). Threshold values for oxygen consumption (VO

resultsHRVT2 showed moderate-to-strong associations with VT2 for VO

conclusionIn CHF patients, HRVT2 appears to be a valid, practical surrogate for VT2 and may facilitate personalised intensity prescription where full CPET is unavailable. HRVT1 showed insufficient agreement with VT1 and should be used with caution. Larger cohorts and protocol refinements are warranted to confirm these observations and to explore strategies for improving HRVT1 accuracy.

Indexed as

Heart FailureHeart RateAgedAnaerobic ThresholdExercise TestFemaleHumansMaleMiddle AgedOxygen ConsumptionAerobic exerciseAutonomic nervous systemCardiac rehabilitationCardiopulmonary exercise testDFA a1Ventilatory thresholds

Identifiers

PMID40560409
PMCPMC12678569

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.