Evidence map›Paper›PMID 40560407›Full record

ReviewCancer immunology, immunotherapy : CII2025

T cell-derived small extracellular vesicles in cancer-immune interactions.

Ma Janelle Chichoco Garcia, Su Su Thae Hnit, Elena Shklovskaya, Yuling Wang

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer immunology, immunotherapy : CII, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Ma Janelle Chichoco GarciaSchool of Natural Sciences, Faculty of Science and Engineering, Macquarie University, Sydney, NSW, 2109, Australia.
Su Su Thae HnitSchool of Natural Sciences, Faculty of Science and Engineering, Macquarie University, Sydney, NSW, 2109, Australia.
Elena ShklovskayaMacquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, 2109, Australia.
Yuling WangSchool of Natural Sciences, Faculty of Science and Engineering, Macquarie University, Sydney, NSW, 2109, Australia. yuling.wang@mq.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small extracellular vesicles (sEVs) are lipid-encapsulated nanoparticles released following the endocytic fusion of multivesicular bodies with the plasma membrane. sEVs are secreted by most eukaryotic cells, and they contain proteins, RNAs and DNA. They act primarily as mediators of intercellular communication through the transport of their contents from donor to recipient cells. Immune cells, including T cells, secrete sEVs following activation. T cell-derived sEVs (T-sEVs) have gained attention in cell-to-cell signalling and as promising immunotherapeutic agents. Growing evidence suggests that T-sEVs are key players in cancer immunotherapy responses. A better understanding of T-sEVs production and properties is key for grasping their biological functions. Extensive current literature on tumour-derived sEVs and their applications in diagnostics or therapeutics is in disconnect with fewer reports on T-sEVs. In this review, we discuss T-sEV biogenesis, their roles in cell-to-cell communication and potential applications in immunotherapy for cancer.

Indexed as

Extracellular VesiclesNeoplasmsT-LymphocytesAnimalsCell CommunicationHumansImmunotherapyCD4+ T cellsCD8+ T cellsIntercellular communicationSmall extracellular vesiclesT cells

Identifiers

PMID40560407
PMCPMC12198105

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.