Evidence map›Paper›PMID 40560375›Full record

ArticleDeutsches Arzteblatt international2025

Fecal Occult Blood Tests for Colorectal Cancer Screening in Routine Medical Care: A Longitudinal Analysis From Germany.

Leon Klimeck, Thomas Heisser, Beata Hennig, Christian Graf, Michael Hoffmeister, Hermann Brenner

Abstract read
In one paragraph

Article in Deutsches Arzteblatt international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. [Cancer prevention and screening].Innere Medizin (Heidelberg, Germany) · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Leon KlimeckClinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg
Thomas HeisserClinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg
Beata HennigBARMER, Berlin
Christian GrafBARMER, Berlin
Michael HoffmeisterClinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg
Hermann BrennerClinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWell-organized programs for colorectal cancer (CRC) screening with fecal occult blood testing (FOBT) can reach over 70% of the eligible population. FOBT was opportunistic in Germany up to 2019. Until March 2025, it was offered annually to persons aged 50 to 54 and twice per year to persons aged 55 and above. Cross-sectional analyses revealed only moderate annual adherence rates, but it remained unclear whether the tests were used regularly by a small share of the population or sporadically by a large share of the population.

methodsWe used anonymized data from BARMER, a German statutory health insurance carrier, to study trends in adherence to annual FOBT screening among persons aged 50 to 54 over the years 2010-2022. The data pertained to 945 214 men and women who were born in the period 1960-1968.

resultsDespite the offer of annual screening, only 22.5% of men and 55.1% of women had at least one FOBT between the ages of 50 and 54. Only 0.1% of men and 1.8% of women used the screening annually as offered. The use of screening has declined even further in recent years. CRC was found in 1.4% of follow-up colonoscopies in both men and women.

conclusionThe opportunistic mode of offering annual FOBT for CRC screening in Germany is highly ineffective, as most of the eligible population did not have even a single test from age 50 to age 54.

Indexed as

Colorectal NeoplasmsEarly Detection of CancerMass ScreeningOccult BloodAgedCross-Sectional StudiesFemaleGermanyHumansLongitudinal StudiesMaleMiddle Aged

Identifiers

PMID40560375
PMCPMC13266562

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.