ArticleSmall (Weinheim an der Bergstrasse, Germany)2025
Vapor-Assisted Mechanochemical Synthesis of Enzyme and Hydrogen-Bonded Organic Framework Biocomposites.
Article in Small (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Green and Ultrafast Preparation of TiOMolecules (Basel, Switzerland) · 2026Article
- All-in-One photo-biocatalysis system for sustainable chemical transformations.Nature communications · 2026Article
- Reticular Chemistry: A Versatile Platform for Engineering Heterogenous Biocatalysts.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Vapor-Assisted Mechanochemical Synthesis of Enzyme and Hydrogen-Bonded Organic Framework Biocomposites.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Hydrogen-bonded Organic Frameworks (HOFs) emerged as a matrix for preparing highly active and stable enzyme biocomposites. Conventional biocompatible synthetic procedures in solutions, however, suffer from issues related to competition with the solvent molecules and inhomogeneous loading of the enzyme. Here, it is demonstrated that a combination of mechanochemistry and accelerated aging can be used to synthesize Hydrogen-bonded Organic Framework (HOF) biocomposites with improved enzyme loading, activity, and protection. Advanced characterization techniques, including in situ Wide-Angle X-ray Scattering and Transmission Electron Microscopy, provide insights into these biocomposites' formation mechanisms and structural properties. A comparative analysis with biocomposites prepared via conventional solution synthesis reveals that vapor-induced growth enhances protein loading, ensures a more homogeneous enzyme distribution, and improves protective properties due to distinct growth mechanisms and kinetics. This simple and green synthetic approach offers a viable alternative to innovative HOF-based composite materials.
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Registered trials
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