ArticleIrish journal of medical science2025
The patient perspective on use of Omalizumab in the in-hospital setting.
Article in Irish journal of medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors.
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Abstract
backgroundOmalizumab is approved for the treatment of chronic spontaneous urticaria (CSU), allergic asthma, and chronic rhinosinusitis with nasal polyps. While self-administration is licensed in Ireland, reimbursement restrictions require hospital-based delivery, placing significant burdens on patients and healthcare services.
aimsTo evaluate patient perspectives on hospital-based administration of Omalizumab, and assess the practical, financial, and environmental implications of current practices, alongside interest in transitioning to home-based therapy.
methodsA cross-sectional survey was conducted among patients receiving Omalizumab in a tertiary referral hospital between December 2024 and January 2025. Eligible participants (n=49) completed a 20- question anonymous questionnaire exploring demographics, treatment burden, and attitudes toward home therapy. Cost data were obtained from institutional finance records.
resultsAmong 49 respondents (98% response rate), 46.9% reported personal costs of €11-€50 per hospital visit, with some incurring over €1,300 annually. Over one quarter (26.5%) missed more than 11 workdays per year due to treatment. Most travelled by private vehicle, generating an estimated 2.1 tonnes of CO₂ annually. A majority (77.5%) would prefer home therapy, citing convenience, flexibility, and reduced financial burden. Annual institutional costs for hospital-based administration of Omalizumab exceeded €1 million, excluding drug expenditure.
conclusionsHospital-based administration of Omalizumab imposes significant patient and system-level costs. These findings support a transition to reimbursed self-administration at home, which may improve patient satisfaction, reduce absenteeism, minimise environmental impact, and achieve considerable healthcare savings.
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