Evidence map›Paper›PMID 40560248›Full record

ArticleJournal of neural transmission (Vienna, Austria : 1996)2026

Sensitivity to negative-feedback processing in people with Parkinson's disease and impulsive-compulsive behaviours.

Alice Martini, Nicola Edelstyn, Luca Weis, Stefano Tamburin, Roberta Schifano, Joseph L Brooks, Elisa Mantovani, James A Grange, Matteo Francesco Lauriola, Francesca Pistonesi and 3 more

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Article in Journal of neural transmission (Vienna, Austria : 1996), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Alice MartiniSchool of Psychology, Keele University, Keele, UK. alice.martini.2@gmail.com.ORCID http://orcid.org/0000-0002-6349-0831
Nicola EdelstynSchool of Psychology, Keele University, Keele, UK.
Luca WeisIRCCS San Camillo Hospital, Venice, Italy.
Stefano TamburinDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Roberta SchifanoIRCCS San Camillo Hospital, Venice, Italy.
Joseph L BrooksSchool of Psychology, Keele University, Keele, UK.
Elisa MantovaniDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
James A GrangeSchool of Psychology, Keele University, Keele, UK.
Matteo Francesco LauriolaDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Francesca PistonesiParkinson and Movement Disorders Unit, Study Center for Neurodegeneration (CESNE), Department of Neuroscience, Padua Neuroscience Center (PNC), University of Padua, Padua, Italy.
Giuseppe LeoniSchool of Psychology, Keele University, Keele, UK.
Angelo AntoniniIRCCS San Camillo Hospital, Venice, Italy.
Roberta BiundoIRCCS San Camillo Hospital, Venice, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biomarkers of impulsive compulsive behaviours (ICBs) in Parkinson’s disease (PD) are lacking. We combined behavioural and electrophysiological markers of sensitivity to negative feedback to address this lack of knowledge. Eighteen PD patients (ICB+, N = 8; ICB-, N = 10) underwent electroencephalography during the Balloon Analogue Risk Task (BART), a measure of risky behaviour, and the feedback-related negativity (FRN), a measure of negative feedback processing, was recorded. Participants also completed the Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease Rating Scale (QUIP-rs), and underwent cognitive, affective and motivation measures. Behaviour on the BART and FRN measures did not differ between the ICB + and ICB- groups. However, a significant positive correlation was observed between the amplitude of the FRN at the Cz electrode and the BART discrepancy score when the two groups were combined into one PD group (rs(18) = 0.52, p = 0.03; 95% CI = 0.07, 0.80). No additional correlations were found between FRN amplitudes and the QUIP-rs score, nor with cognitive, affective, or motivational measures. Our findings indicate that, regardless of ICB status, PD patients may be able to process negative feedback to mitigate risky behaviour during reward-related decision-making. We observed that a higher feedback-related negativity (FRN) is linked to a decrease in risky behaviour following a balloon burst. However, due to the small sample size, these findings should be interpreted with caution. Future studies should explore both positive and negative feedback processing using a task that maintains the dynamics of the ongoing decision-making process while increasing risk.

Indexed as

Compulsive BehaviorFeedback, PsychologicalImpulsive BehaviorParkinson DiseaseAgedElectroencephalographyEvoked PotentialsFemaleHumansMaleMiddle AgedRisk-TakingBARTDecision-makingERPImpulsive-compulsive behavioursNegative-feedback processingParkinson’s disease

Identifiers

PMID40560248

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.