Evidence map›Paper›PMID 40560112›Full record

ArticleJACC. Asia2025

Systolic Dyssynchrony Index in Hypertrophic Cardiomyopathy: Association With Ventricular Arrhythmias and Risk Prediction.

Rong Wang, Haiming Zhuang, Nan Xu, Li Zhang, Jiayi Xing, Tingting Zhang, Lianming Kang, Lei Song, Kunjing Pang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Asia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rong WangDepartment of Echocardiography, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Haiming ZhuangDepartment of Echocardiography, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Nan XuDepartment of Echocardiography, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Li ZhangDepartment of Echocardiography, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Jiayi XingDepartment of Echocardiography, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Tingting ZhangDepartment of Echocardiography, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Lianming KangDepartment of Cardiovascular Internal Medicine, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Lei SongDepartment of Cardiovascular Internal Medicine, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address: songlqd@126.com.
Kunjing PangDepartment of Echocardiography, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address: pangkunjing2020@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMechanical dispersion (MD) has been demonstrated to be associated with nonsustained ventricular tachycardia (NSVT) and could potentially predict sudden cardiac death in hypertrophic cardiomyopathy (HCM) patients.

objectivesThe authors sought to evaluate the systolic dyssynchrony index (SDI) measured with 3-dimensional echocardiography and explore its predictive value for risk assessment in HCM patients.

methodsA total of 610 HCM patients were prospectively enrolled, and we measured the MD and SDI. Their associations with NSVT and guideline-based implantable cardioverter-defibrillator class of recommendation (ICD-COR) were analyzed.

resultsA total of 81 (13.28%) patients were diagnosed with NSVT by the 24-hour Holter monitoring. The SDI of HCM patients with NSVT was significantly higher than that of HCM patients without NSVT (8.60% (7.00%-10.80%) vs. 6.00% (4.70%-7.15%). P = 0.000). The SDI was independently associated with the presence of NSVT (OR: 1.57; P = 0.000). The SDI identified NSVT in HCM patients with an area under the curve of 0.79 at a cutoff value of 7.58%, which was significantly higher than MD, with an area under the curve of 0.70 (P = 0.025). The percentages for Class IIa ICD-COR in HCM patients with SDI ≥7.58% were significantly higher than those in HCM patients with SDI <7.58% according the current guidelines.

conclusionsThe SDI was more capable of assessing mechanical dyssynchrony and detecting NSVT in HCM patients compared with MD. The SDI might serve to identify HCM patients eligible for Class IIa ICD-COR according to current guidelines.

Indexed as

hypertrophic cardiomyopathymechanical dyssynchronyrisk assessmentventricular tachycardia

Identifiers

PMID40560112
PMCPMC12426848

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.