ArticleTomography (Ann Arbor, Mich.)2025
Assessment of Mandibular Bone Architecture in Patients with Endocrine Disorders Using Fractal Dimension and Histogram Analysis.
Article in Tomography (Ann Arbor, Mich.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Mandibular trabecular fractal dimension in individuals with type 2 diabetes and hypertension: a retrospective cross-sectional panoramic radiography study.BMC oral health · 2026Article
- Vücut kitle indeksinin mandibular kemik mimarisi üzerindeki etkileri: retrospektif fraktal boyut ve radyomorfometrik analiz.Clinical oral investigations · 2026Article
- Hypothyroidism and Mandibular Cortical Alterations Evaluated on Panoramic Radiography: A Cross-Sectional Study in Women.Healthcare (Basel, Switzerland) · 2025Article
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Authors and funding
6 authors.
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Abstract
objectiveEndocrine disorders, including diabetes mellitus and thyroid dysfunctions, can significantly impact bone metabolism and structure. This study aimed to assess mandibular trabecular architecture in patients with type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), hyperthyroidism, and hypothyroidism using fractal dimension (FD) and histogram analyses (HA), comparing the findings with a healthy control group.
methodsThis retrospective study analyzed panoramic radiographs from 200 individuals, comprising 40 patients in each of the four endocrine disorder groups and 40 healthy controls. Fractal dimension and histogram-based pixel intensity analyses were conducted using ImageJ™ (version 1.53) software. Four standardized regions of interest (ROI) were evaluated on the right mandible, and statistical comparisons were conducted across groups using one-way analysis of variance (ANOVA),
resultsAge and gender distributions did not differ significantly between groups. FD analysis revealed a significant reduction at ROI1 in the hyperthyroidism group compared to controls (
conclusionAlthough no significant differences were found in diabetic groups, the decreased FD in hyperthyroid patients suggests that FD analysis may be a useful non-invasive method to detect subtle bone alterations. Further research with larger sample sizes and comprehensive biochemical analyses are needed to confirm these findings.
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