Evidence map›Paper›PMID 40559999›Full record

ArticleNucleic acid therapeutics2025

Exosome-Mediated Mitochondrial Delivery of Antisense Oligonucleotides.

Dora von Trentini, Ivan J Dmochowski

Abstract read
In one paragraph

Article in Nucleic acid therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Dora von TrentiniDepartment of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ivan J DmochowskiDepartment of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-7162-1347

Funding

Designer Molecular Probes for Biomedical ApplicationsR35GM131907 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Ivan Julian Dmochowski · 2019 to 2026
$4.7M
NIGMS NIH HHS R35 GM131907
6 · The paper itself

Abstract

We present a general method for in-cellulo delivery of 2'-

Indexed as

ExosomesMitochondriaMitochondrial DiseasesOligonucleotides, AntisenseAnimalsCattleDNA, MitochondrialHumansDNA, MitochondrialOligonucleotides, Antisense2′-OMe RNAantisense oligonucleotidesexosome-based deliveryextracellular vesiclesfetal bovine serummitochondrial localization

Identifiers

PMID40559999
PMCPMC12411094

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.