Evidence map›Paper›PMID 40559993›Full record

ArticleProteomes2025

Knowledge Discovery in Databases of Proteomics by Systems Modeling in Translational Research on Pancreatic Cancer.

Mathilde Resell, Elisabeth Pimpisa Graarud, Hanne-Line Rabben, Animesh Sharma, Lars Hagen, Linh Hoang, Nan T Skogaker, Anne Aarvik, Magnus K Svensson, Manoj Amrutkar and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proteomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Mathilde ResellDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7030 Trondheim, Norway.
Elisabeth Pimpisa GraarudDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7030 Trondheim, Norway.
Hanne-Line RabbenDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7030 Trondheim, Norway.
Animesh SharmaPROMEC-Proteomics and Modomics Experimental Core Facility at NTNU and the Central Norway Regional Health Authority, 7030 Trondheim, Norway.ORCID 0000-0002-8791-4635
Lars HagenPROMEC-Proteomics and Modomics Experimental Core Facility at NTNU and the Central Norway Regional Health Authority, 7030 Trondheim, Norway.
Linh HoangDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7030 Trondheim, Norway.
Nan T SkogakerDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7030 Trondheim, Norway.
Anne AarvikDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7030 Trondheim, Norway.
Magnus K SvenssonDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7030 Trondheim, Norway.
Manoj AmrutkarDepartment of Pathology, Oslo University Hospital, 0372 Oslo, Norway.ORCID 0000-0002-1868-0249
Caroline S VerbekeDepartment of Pathology, Oslo University Hospital, 0372 Oslo, Norway.ORCID 0000-0002-1111-9715
Surinder K BatraDepartment Biochemistry and Molecular Biology, University of Nebraska College of Medicine, Omaha, NE 68198, USA.ORCID 0000-0001-9470-9317
Gunnar QvigstadDepartment of Gastroenterology, St. Olav's Hospital, 7030 Trondheim, Norway.
Timothy C WangDivision of Digestive and Liver Diseases, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA.
Anil RustgiDivision of Digestive and Liver Diseases, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA.
Duan ChenDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7030 Trondheim, Norway.
Chun-Mei ZhaoDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7030 Trondheim, Norway.

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
NCI NIH HHS P30 CA013696NIH HHS P30CA013696 and its Proteomics and Structural Biology Shared Resource
6 · The paper itself

Abstract

backgroundKnowledge discovery in databases (KDD) can contribute to translational research, also known as translational medicine, by bridging the gap between

methodsThis framework includes the data collection of a composition model (various research models), processing model (proteomics) and analytical model (bioinformatics, artificial intelligence/machine leaning and pattern evaluation), knowledge presentation, and feedback loops for hypothesis generation and validation. We applied this workflow to study pancreatic ductal adenocarcinoma (PDAC).

resultsWe identified the common proteins between human PDAC and various research models

conclusionsThis systems modeling workflow can be a valuable method for KDD, facilitating knowledge discovery in translational targets in general, and in particular to PADA in this case.

Indexed as

bioinformaticsnetworksproteomicsresearch modelssignaling pathways

Identifiers

PMID40559993
PMCPMC12196815

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.