Unraveling the Central Role of Global Regulator PprI in

Siyu Zhu, Feng Liu, Hao Wang, Yongqian Zhang

Abstract read

In one paragraph

Article in Proteomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Rising from the fragments: a multi-factorial regulatory framework of DNA damage response in Deinococcus radiodurans.Extremophiles : life under extreme conditions · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Siyu ZhuSchool of Medical Technology, Beijing Institute of Technology, No. 5 Zhongguancun South Street, Beijing 100081, China.

Feng LiuSchool of Medical Technology, Beijing Institute of Technology, No. 5 Zhongguancun South Street, Beijing 100081, China.

Hao WangSchool of Medical Technology, Beijing Institute of Technology, No. 5 Zhongguancun South Street, Beijing 100081, China.

Yongqian ZhangSchool of Medical Technology, Beijing Institute of Technology, No. 5 Zhongguancun South Street, Beijing 100081, China.ORCID 0000-0003-1047-3701

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

methodsBuilding upon these foundations, our study employs label-free quantitative (LFQ) proteomics coupled with high-resolution mass spectrometry to systematically map

resultsUnder stringent screening criteria, we identified 719 significantly higher and 281 significantly lower abundant proteins in the knockout strain compared to wild-type strains. Functional analysis revealed that PprI deficiency disrupts homologous recombination (HR) repair, activates nucleotide excision repair (NER) and base excision repair (BER) as a compensatory mechanism, and impairs Mn/Fe homeostasis and carotenoid biosynthesis, leading to increased oxidative stress. Furthermore, PprI deficiency induces significant metabolic reprogramming, including impaired purine synthesis, compromised cell wall integrity, etc. Conclusions: These proteomic findings delineate the extensive regulatory network influenced by PprI, revealing coordinated perturbations across multiple stress response systems when PprI is absent.

Indexed as

antioxidant defenseDNA damage repairlabel-free quantitative proteomicsmetabolic regulationradiation response metalloprotease

Identifiers

PMID40559992

DOI10.3390/proteomes13020019

PMCPMC12197293

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.