Evidence map›Paper›PMID 40559939›Full record

ArticleToxics2025

Addressing the Global Challenge of Nitrous Oxide Misuse Through a Multidisciplinary Approach: Example of the PROTOSIDE Network.

Guillaume Grzych, Remy Diesnis, Thierry Dupré, Jean Paul Niguet, Emeline Gernez, Damien Denimal, Sylvie Deheul, Jean Claude Guichard, Damien Scliffet, Bruno Mégarbane and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Spinal cord syndrome: uncovering the risks of nitrous oxide abuse.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Guillaume GrzychCHU Lille, Service Biochimie Automatisée-Protéines, 59000 Lille, France.
Remy DiesnisEmergency Departement, CH Roubaix, 59100 Roubaix, France.ORCID 0000-0001-7938-4091
Thierry DupréDépartement de Biochimie, AP-HP, Hôpital Bichat, Biochimie, 75018 Paris, France.
Jean Paul NiguetService de Neurologie, Hôpital Saint Vincent de Paul-GHICL, 59000 Lille, France.
Emeline GernezCHU de Lille, Centre de Biologie Pathologie Génétique, 59000 Lille, France.
Damien DenimalCHU Dijon Bourgogne, INSERM U1231, Université Bourgogne Europe, 21000 Dijon, France.
Sylvie DeheulInserm, UMR S1171, CHU Lille, Service de Pharmacologie Médicale, Université de Lille, 59000 Lille, France.
Jean Claude GuichardUnité Sanitaire en Milieu Pénitentiaire USMP, 59000 Lille, France.
Damien ScliffetCH de Lens, Addictologie, 62300 Lens, France.ORCID 0000-0003-0761-3654
Bruno MégarbaneRéanimation Médicale et Toxicologique, Hôpital Lariboisière, Université Paris Cité, 75013 Paris, France.ORCID 0000-0002-2522-2764
Isabelle Redonnet-VernhetBiochimie, CHU Bordeaux, INSERM U1211 MRGM, Université Bordeaux, 33076 Bordeaux, France.
Alexandra BoucherCentre d'Addictovigilance, Hospices Civils de Lyon, 69000 Lyon, France.
Anas BennisAssistance Publique-Hôpitaux de Paris, Service de Neurologie, Groupe Hospitalier Universitaire Paris Sud, Hôpital Bicêtre, 94270 Le Kremlin-Bicêtre, France.
Laurent KarilaCentre d'Enseignement, de Recherche et de Traitement des Addictions, Hôpital Universitaire Paul-Brousse (AP-HP), Université Paris-Saclay, 94804 Villejuif, France.
Etienne CavalierDepartment of Clinical Chemistry, CIRM, University of Liege, 4000 Liège, Belgium.
Benjamin RollandService Universitaire d'Addictologie de Lyon (SUAL), Hospices Civils de Lyon, CH Le Vinatier, 69002 Lyon, France.
Christophe RiouService Universitaire d'Addictologie de Lyon (SUAL), Hospices Civils de Lyon, CH Le Vinatier, 69002 Lyon, France.
Cécile BossaertCHU de Lille, Service des Urgences Adultes, SAMU, 59000 Lille, France.ORCID 0009-0006-0240-8255
Anthony ChauvinEmergency Department, Hôpital Lariboisière, APHP, 75010 Paris, France.ORCID 0000-0001-8819-0061
multidisciplinary network PROTOSIDE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nitrous oxide (N

Indexed as

addictionbiomarkershomocysteineinternational networkmethylmalonic acidmultidisciplinaryneurologynitrous oxidetoxicology

Identifiers

PMID40559939
PMCPMC12197755

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.