Evidence map›Paper›PMID 40559857›Full record

ArticleToxins2025

Cvill6 and Cvill7: Potent and Selective Peptide Blockers of Kv1.2 Ion Channel Isolated from Mexican Scorpion

Kashmala Shakeel, Muhammad Umair Naseem, Timoteo Olamendi-Portugal, Fernando Z Zamudio, Lourival Domingos Possani, Gyorgy Panyi

Abstract read
In one paragraph

Article in Toxins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kashmala ShakeelDepartment of Biophysics and Cell Biology, Faculty of Medicine, Research Center for Molecular Medicine, University of Debrecen, Egyetem ter. 1, 4032 Debrecen, Hungary.ORCID 0000-0002-4284-6640
Muhammad Umair NaseemDepartment of Biophysics and Cell Biology, Faculty of Medicine, Research Center for Molecular Medicine, University of Debrecen, Egyetem ter. 1, 4032 Debrecen, Hungary.ORCID 0000-0003-3849-6219
Timoteo Olamendi-PortugalDepartamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnologia, Universidad Nacional Autónoma de México, Av. Universidad 2001, Cuernavaca 62210, Mexico.
Fernando Z ZamudioDepartamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnologia, Universidad Nacional Autónoma de México, Av. Universidad 2001, Cuernavaca 62210, Mexico.
Lourival Domingos PossaniDepartamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnologia, Universidad Nacional Autónoma de México, Av. Universidad 2001, Cuernavaca 62210, Mexico.ORCID 0000-0001-6357-2661
Gyorgy PanyiDepartment of Biophysics and Cell Biology, Faculty of Medicine, Research Center for Molecular Medicine, University of Debrecen, Egyetem ter. 1, 4032 Debrecen, Hungary.ORCID 0000-0001-6227-3301

Funding

Hungarian National Research, Development, and Innovation Office K143071Ministry of Culture and Innovation of Hungary from the National Research, Development and Innovation Fund 2024-1.2.3-HU-RIZONT-2024-00099National Council of Science and Technology of Mexico CONACYT 303045
6 · The paper itself

Abstract

Scorpion venoms are a rich source of peptides that modulate the activity of ion channels and can serve as a new drug for channelopathies. Cvill6 and Cvill7 are two new peptides isolated from the venom of

Indexed as

Kv1.2 Potassium ChannelPeptidesPotassium Channel BlockersScorpionsScorpion VenomsAmino Acid SequenceAnimalsAnimals, PoisonousHumansKv1.3 Potassium ChannelMolecular Sequence DataKv1.2 Potassium ChannelKv1.3 Potassium ChannelPeptidesPotassium Channel BlockersScorpion VenomsCentruroides villegasi peptidesKCa3.1Kv1.2Kv1.3patch-clampelectrophysiologyscorpion toxinα-KTx

Identifiers

PMID40559857
PMCPMC12197678

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.