Evidence map›Paper›PMID 40559827›Full record

ArticleVeterinary sciences2025

Use of Colorimetry for the Measurement of Intradermally Injected Histamine-Induced Erythema in Healthy Dogs: A Proof-of-Concept Study.

Ana Petak, Elisa Samuel Badulescu, Svetlina Aleksandrova, Evi I Sofou, Manolis K Chatzis, Manolis N Saridomichelakis

Abstract read
In one paragraph

Article in Veterinary sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ana PetakClinic of Medicine, Faculty of Veterinary Science, University of Thessaly, Trikalon Str. 224, 43 132 Karditsa, Greece.ORCID 0000-0002-2367-5364
Elisa Samuel BadulescuClinic of Medicine, Faculty of Veterinary Science, University of Thessaly, Trikalon Str. 224, 43 132 Karditsa, Greece.ORCID 0000-0002-4478-3591
Svetlina AleksandrovaClinic of Medicine, Faculty of Veterinary Science, University of Thessaly, Trikalon Str. 224, 43 132 Karditsa, Greece.
Evi I SofouClinic of Medicine, Faculty of Veterinary Science, University of Thessaly, Trikalon Str. 224, 43 132 Karditsa, Greece.ORCID 0000-0001-8600-8385
Manolis K ChatzisClinic of Medicine, Faculty of Veterinary Science, University of Thessaly, Trikalon Str. 224, 43 132 Karditsa, Greece.ORCID 0000-0001-8451-3708
Manolis N SaridomichelakisClinic of Medicine, Faculty of Veterinary Science, University of Thessaly, Trikalon Str. 224, 43 132 Karditsa, Greece.ORCID 0000-0001-8308-3371

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The interpretation of intradermal test results may improve if wheal erythema is measured objectively using colorimetry. Our aim was to find the necessary number of erythema colorimetric measurements, taken before and after intradermal injections of histamine 0.01% (H1), histamine 0.001% (H2), histamine 0.0001% (H3) and a negative control (NC). We also aimed to assess whether erythema should be measured at the wheal center or border, and to investigate whether erythema appears beyond histamine wheals (flare), as observed in humans. Duplicate injections of the four solutions were administered on the lateral thorax of seven healthy dogs and erythema was measured by removing and repositioning the colorimeter probe. Colorimetry can differentiate the change in erythema (

Indexed as

colorimetryerythemaflare reactionhistamineintradermal testwheal

Identifiers

PMID40559827
PMCPMC12197380

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.