ReviewSports (Basel, Switzerland)2025
Evaluating the Effects of Exercise on Inflammation Markers in Musculoskeletal Pain: A Systematic Review and Meta-Analysis.
Review in Sports (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The impact of exercise on inflammatory biomarkers: an umbrella review of systematic reviews and meta-analyses.Frontiers in immunology · 2026Pooled it
- Optimizing resistance training for pain management in knee and hip osteoarthritis: a pairwise and dose-response meta-analysis.Frontiers in public health · 2025Pooled it
- Inflammaging and Sarcopenia as Interconnected Hallmarks of Aging: Integrative Roles of Bioactive Compounds and Lifestyle Interventions.Nutrients · 2026Review
- Rehabilitation modalities in ankylosing spondylitis: orthopaedic perspectives on function, bone health, and surgical safety.Journal of orthopaedics · 2026Review
- Immunomodulatory Effects of Acupuncture on Inflammatory Markers in Patients with Musculoskeletal Pain: A Systematic Review of Randomized Controlled Trials.Muscles (Basel, Switzerland) · 2026Review
- Physical Activity and Health-Related Quality of Life in Kidney Transplant Recipients: A Cross-Sectional Exploratory Study of Clinical and Inflammatory Parameters.Healthcare (Basel, Switzerland) · 2026Article
- Exploring the nexus between inflammation and mobility through the lens of healthy aging: current scenario and future perspectives.Aging clinical and experimental research · 2026Review
- Pressure point: blood flow restriction exercise and the pain paradox in musculoskeletal injury and persistent pain populations-a narrative review.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Effects of 8 weeks of moderate physical training on body composition, lipid profile, inflammatory markers, and physical activity in middle aged females.Frontiers in endocrinology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This systematic review and meta-analysis aimed to investigate the effectiveness of exercise interventions in regulating inflammatory biomarkers among individuals with musculoskeletal pain. A comprehensive search of MEDLINE, CINAHL, Web of Science, Cochrane Library, and Google Scholar was conducted from inception to November 2024. Only randomized controlled trials (RCTs) published in English that examined the effects of exercise on inflammatory markers-such as C-reactive protein (CRP), interleukins (ILs), and tumor necrosis factor-alpha (TNF-α)-were included. Twenty-three RCTs involving 1128 participants met the inclusion criteria. Meta-analysis of four studies indicated that isokinetic exercise significantly reduced CRP (MD = -0.40, 95% CI: -0.44 to -0.36,
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.