Evidence map›Paper›PMID 40559607›Full record

ArticlePathogens (Basel, Switzerland)2025

Bat Influenza M2 Shows Functions Similar to Those of Classical Influenza A Viruses.

Wenyu Yang, Liping Wang, Lei Shi, Jialin Zhang, Heidi Liu, Jun Wang, Wenjun Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wenyu YangDepartment of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA.
Liping WangDepartment of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA.
Lei ShiDepartment of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA.ORCID 0000-0003-2543-0042
Jialin ZhangDepartment of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA.ORCID 0009-0005-6656-7047
Heidi LiuDepartment of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA.
Jun WangDepartment of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.ORCID 0000-0002-4845-4621
Wenjun MaDepartment of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA.

Funding

NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00016 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI WEBBY, RICHARD · 2021 to 2025
$91.4M
Biology and infection of bats with novel bat influenza virusesR01AI134768 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI MA, WENJUN · 2018 to 2022
$2.1M
Centers of Excellence in Influenza Research and Response (CEIRR) funded by NIAID contract number 75N93021C00016NIAID NIH HHS 75N93021C00016NIAID NIH HHS R01 AI134768NIH HHS 1R01TW134768-20
6 · The paper itself

Abstract

Novel bat influenza viruses show different features in contrast to classical influenza A viruses (IAVs). The M2 of IAVs functions as an ion channel that plays an important role in virus entry, viral assembly, and release and also serves as the antiviral target. To date, whether bat influenza M2 functions as the ion channel like classical IAV M2 remains unknown. Here, we show that the bat influenza M2 amino acid at position 31 (N/S) is critical for sensitivity to antivirals targeting the ion channel such as amantadine and other tested antivirals and that the amino acids at position 37 (H/G) and 41 (W/A) are crucial for virus replication and survival. The results indicate that bat influenza M2 functions similarly to conventional IAVs despite the low identity between the two.

Indexed as

ChiropteraInfluenza A virusOrthomyxoviridae InfectionsViral Matrix ProteinsAmantadineAnimalsAntiviral AgentsDogsHumansMadin Darby Canine Kidney CellsViroporin ProteinsVirus ReplicationAmantadineAntiviral AgentsM2 protein, Influenza A virusViral Matrix ProteinsViroporin Proteinsantiviral resistancebat influenza M2ion channel

Identifiers

PMID40559607
PMCPMC12195650

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.