Evidence map›Paper›PMID 40559582›Full record

ArticlePathogens (Basel, Switzerland)2025

Systemic Antifolate Chemotherapy Does Not Select for Fluconazole-Resistant

Dawid Żyrek, Joanna Nowicka, Magdalena Pajączkowska, Mariola Paściak, Katarzyna Machnik, Tomasz Werner, Zygmunt Konieczny, Piotr Jędrzejczak, Dominika Raźniewska, Gabriela Fijałkowska and 5 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Dawid ŻyrekDepartment of Histology, Institute of Medical Sciences, University of Opole, 45-052 Opole, Poland.ORCID 0000-0002-9921-0811
Joanna NowickaDepartment of Microbiology, Faculty of Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland.ORCID 0000-0002-4001-4189
Magdalena PajączkowskaDepartment of Microbiology, Faculty of Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland.ORCID 0000-0002-9881-8294
Mariola PaściakHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wroclaw, Poland.ORCID 0000-0002-2603-4634
Katarzyna MachnikHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wroclaw, Poland.
Tomasz WernerClinical Department of Pulmonology, Institute of Medical Sciences, University of Opole, 45-052 Opole, Poland.
Zygmunt KoniecznyDepartment of Pulmonology with a Chemotherapy Subunit, Hospital in Glucholazy, Lompy 3, 48-340 Glucholazy, Poland.
Piotr JędrzejczakDepartment of Clinical Oncology, Lower Silesian Center of Oncology, Pulmonology and Hematology, Grabiszyńska 105, 53-439 Wroclaw, Poland.
Dominika RaźniewskaDepartment of Oncology, Institute of Medical Sciences, University of Opole, 45-040 Opole, Poland.
Gabriela FijałkowskaClinical Department of Pulmonology, Institute of Medical Sciences, University of Opole, 45-052 Opole, Poland.
Michał PiątekDepartment of Oncology, Institute of Medical Sciences, University of Opole, 45-040 Opole, Poland.
Barbara RadeckaDepartment of Oncology, Institute of Medical Sciences, University of Opole, 45-040 Opole, Poland.
Kinga ŻyrekDivision of Physiotherapy, Faculty of Health Sciences, Wroclaw Medical University, 50-367 Wroclaw, Poland.
Elżbieta Woźniak-GrygielDepartment of Histology, Institute of Medical Sciences, University of Opole, 45-052 Opole, Poland.ORCID 0000-0002-3240-1939
Iwona Dzieńdziora-UrbińskaDepartment of Histology, Institute of Medical Sciences, University of Opole, 45-052 Opole, Poland.ORCID 0000-0002-5800-7817

Funding

University of Opole P-2023-010
6 · The paper itself

Abstract

Previous studies have demonstrated that

Indexed as

Antifungal AgentsCandidaCandidiasisDrug Resistance, FungalFluconazoleFolic Acid AntagonistsAdultAgedAged, 80 and overFemaleHumansMaleMethotrexateMicrobial Sensitivity TestsMiddle AgedNeoplasmsAntifungal AgentsFluconazoleFolic Acid AntagonistsMethotrexatePemetrexedantifolatesCandidacross-resistancedrug-induced resistancemethotrexatepemetrexedyeast

Identifiers

PMID40559582
PMCPMC12195857

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.