Evidence map›Paper›PMID 40559534›Full record

ArticlePathogens (Basel, Switzerland)2025

Generation of Immune Modulating Small Metabolites-Metabokines-By Adult Schistosomes.

Patrick J Skelly, Akram A Da'dara

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Shared urinary metabolomic signatures as potential biomarkers for early intestinalCurrent research in parasitology & vector-borne diseases · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Patrick J SkellyMolecular Helminthology Laboratory, Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.
Akram A Da'daraMolecular Helminthology Laboratory, Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.ORCID 0000-0003-3318-9623

Funding

Gene silencing in schistosomes using RNAiR01AI056273 · NIAID · TUFTS UNIVERSITY BOSTON · PI Patrick J Skelly · 2004 to 2026
$7.2M
Functional Characterization of the Schistosome TegumentR56AI056273 · NIAID · TUFTS UNIVERSITY BOSTON · PI SKELLY, PATRICK J · 2021 to 2021
$413k
National Institute of Allergy and INfectious Diseasses, National Institutes of Health AI056273NIAID NIH HHS R01 AI056273NIAID NIH HHS R56 AI056273
6 · The paper itself

Abstract

Schistosomes are intravascular parasitic worms that cause the debilitating tropical disease schistosomiasis, affecting >200 million people worldwide. How the worms survive within the body of immunocompetent hosts for many years is unclear. Here, using chromatography and mass spectrometry, we report on the ex vivo ability of adult

Indexed as

Schistosoma mansoniSchistosomiasis mansoniAnimalsMiceblood flukeimmunomodulationmetabolomicsparasiteSchistosoma

Identifiers

PMID40559534
PMCPMC12195828

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.