Evidence map›Paper›PMID 40559319›Full record

ArticleNeurology international2025

Identifying Clinical Measures Related to Falls in Ambulatory Patients with Spinal and Bulbar Muscular Atrophy.

Joseph A Shrader, Allison C Niemic, Rafael Jiménez-Silva, Joshua G Woolstenhulme, Galen O Joe, Uma Jacobs, Ashwini Sansare, Angela Kokkinis, Kenneth Fischbeck, Chris Grunseich and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Frequency and Circumstances of Falls Events in People Living With Spinal and Bulbar Muscular Atrophy: A Cross-Sectional Survey.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Joseph A ShraderRehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-8174-0745
Allison C NiemicRehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
Rafael Jiménez-SilvaRehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
Joshua G WoolstenhulmeRehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
Galen O JoeRehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
Uma JacobsRehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0009-0003-7542-2646
Ashwini SansareRehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
Angela KokkinisNeurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Kenneth FischbeckNeurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Chris GrunseichNeurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Cris ZampieriRehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0003-4632-7941

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSpinal and bulbar muscular atrophy (SBMA) is an adult-onset, X-linked, progressive neuromuscular disease caused by abnormal CAG trinucleotide expansion in the androgen receptor gene. Patients with SBMA report difficulty with falls on self-reported activities of daily living scales. To our knowledge, no study has examined the relationship between falls and common clinical measures of strength, balance, mobility, and disease biomarkers. We performed a cross-sectional analysis of an SBMA cohort.

objectivesThe objectives of this study are as follows: (1) compare demographics, clinical measures, and biomarkers between patients who did and did not fall; (2) determine which measures best discriminate fallers from non-fallers; and (3) identify cutoff scores to detect patients with a higher fall risk.

designCross-sectional analysis was used. OUTCOME MEASURES: Disease biomarkers included blood serum creatinine, and clinical measures included the Timed Up and Go (TUG), the Adult Myopathy Assessment Tool (AMAT), and posturography, including the Modified Clinical Test of Sensory Interaction on Balance and the Motor Control Test. The Maximal Voluntary Isometric Contractions (MVICs) of four lower extremity muscles were captured via fixed-frame dynamometry.

resultsWe identified three clinical measures that help detect fall risk in people with SBMA. A post hoc receiver operating characteristic curve analysis helped identify cut scores for each test. Impairments of mobility (TUG > 8 s), muscle endurance (AMAT endurance subscale < 14), and muscle strength (ankle plantar flexion MVIC < 45% of predicted) were different between fallers and non-fallers, via independent

conclusionsThese three clinical tests can help detect fall risk that may help clinicians implement gait aid use or other fall prevention strategies before catastrophic falls occur.

Indexed as

Adult Myopathy Assessment Toolbalancefallsfixed-frame dynamometryKennedy’s diseasemobilityplantarflexor strengthTimed Up and Go

Identifiers

PMID40559319
PMCPMC12195735

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.