Evidence map›Paper›PMID 40559250›Full record

ArticleNanomaterials (Basel, Switzerland)2025

Impact of Atomic Layer-Deposited Hydroxyapatite-Coated Titanium on Expression of Focal Adhesion Molecules of Human Gingival Fibroblasts.

Nagat Areid, Faleh Abushahba, Sini Riivari, Elisa Närvä, Elina Kylmäoja, Mikko Ritala, Juha Tuukkanen, Pekka K Vallittu, Timo O Närhi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nagat AreidDepartment of Prosthetic Dentistry and Stomatognathic Physiology, Institute of Dentistry, University of Turku, FI-20520 Turku, Finland.ORCID 0000-0003-2959-8774
Faleh AbushahbaDepartment of Prosthetic Dentistry and Stomatognathic Physiology, Institute of Dentistry, University of Turku, FI-20520 Turku, Finland.ORCID 0000-0002-8032-9396
Sini RiivariDepartment of Prosthetic Dentistry and Stomatognathic Physiology, Institute of Dentistry, University of Turku, FI-20520 Turku, Finland.ORCID 0000-0002-5475-5973
Elisa NärväInstitute of Biomedicine and FICAN West Cancer Centre Laboratory, University of Turku and Turku University Hospital, FI-20520 Turku, Finland.ORCID 0000-0003-0517-9436
Elina KylmäojaDepartment of Anatomy and Cell Biology, Research Unit of Translational Medicine, Medical Research Center, University of Oulu, FI-90014 Oulu, Finland.ORCID 0000-0003-0821-0718
Mikko RitalaDepartment of Chemistry, University of Helsinki, FI-00014 Helsinki, Finland.ORCID 0000-0002-6210-2980
Juha TuukkanenDepartment of Anatomy and Cell Biology, Research Unit of Translational Medicine, Medical Research Center, University of Oulu, FI-90014 Oulu, Finland.ORCID 0000-0002-1723-6461
Pekka K VallittuDepartment of Biomaterials Science and Turku Clinical Biomaterials Center-TCBC, Institute of Dentistry, University of Turku, FI-20520 Turku, Finland.
Timo O NärhiDepartment of Prosthetic Dentistry and Stomatognathic Physiology, Institute of Dentistry, University of Turku, FI-20520 Turku, Finland.ORCID 0000-0003-1325-4555

Funding

Business Finland Co-innovation IMD1 11/31/2023
6 · The paper itself

Abstract

This study investigated the impact of the nanocrystalline atomic layer-deposited hydroxyapatite (ALD-HA) coating of titanium (Ti) surface on the attachment and proliferation of human gingival fibroblasts (HGFs). Ti discs were divided into ALD-HA-coated and non-coated (NC) controls. HGFs were harvested from gingival biopsies of patients subjected to extraction of their third molar. The cells were cultivated on the Ti discs for 2 and 24 h to evaluate the initial cell attachment using confocal microscopy. Spreading of cells and the signals of focal adhesion proteins were measured. Moreover, the adhesion proteins vinculin and paxillin expression levels were evaluated using Western blot after 3 d of cultivation. In addition, the proliferation of HGF was assessed by cultivating the cells on Ti discs for 1, 3, and 7 d. Fibroblast spreading was significantly greater on ALD-HA surfaces than on NC surfaces after 2 h (

Indexed as

ALDcell adhesiondental implantfocal adhesiongingival tissueimplant surfacetitanium

Identifiers

PMID40559250
PMCPMC12195992

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.