ArticleInsects2025
Adaptive Evolution and Transcriptomic Specialization of P450 Detoxification Genes in the Colorado Potato Beetle Across Developmental Stages and Tissues.
Article in Insects, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Assessing the potential for insecticide cross-resistance to a novel insecticide in the Colorado potato beetle (Leptinotarsa decemlineata) using phenotypic and transcript expression analysis.Pest management science · 2026Article
- Comprehensive Characterization of Cytochrome P450s Reveals Candidate Enzymes Involved in the Metabolic Fate of Absorbed Volatile Organic Compounds in Potato.Antioxidants (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The Colorado potato beetle is a notorious agricultural pest with remarkable adaptability and insecticide resistance. This study conducted comprehensive transcriptome analysis across multiple developmental stages and tissues, focusing on the cytochrome P450 monooxygenase gene family. Using RNA-seq data from 65 datasets, we identified significant transcriptional reprogramming during key developmental transitions, particularly from egg to first instar larva and from third instar larva to adult, reflecting critical biological processes, including feeding initiation and metamorphosis. We identified 3616 tissue-specific genes, with the testis exhibiting the highest transcriptional specialization (1182 genes). Genome-wide screening revealed 78 P450 genes distributed across four major clans with an uneven chromosomal distribution. Expression analysis demonstrated six distinct clusters with tissue and developmental stage-specific patterns. Evolutionary analysis identified five P450 genes under strong positive selection. Analysis of mRNA sequence polymorphisms revealed developmental stage and tissue-dependent patterns, with elevated mutation frequencies in early developmental stages and specific tissues. These distinct tissue and developmental stage-specific mutation patterns in P450 transcripts highlight the dynamic regulation of detoxification genes. Our findings advance the understanding of the molecular mechanisms underlying the beetle's ecological success and provide valuable targets for developing novel pest management strategies.
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