Evidence map›Paper›PMID 40558908›Full record

ArticleJournal of functional biomaterials2025

Enhanced Osteogenesis and Antibacterial Properties of Ketoprofen-Loaded MgCu-MOF74-Coated Titanium Alloy for Bone Implant.

Ziqing Duan, Yifeng Yao, Jiamin Liu, Yanni Tan, Qingge Wang, Man Fang, Aqsa Kanwal, Shuqiao Cheng, Juan Huang, Hong Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of functional biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ziqing DuanState Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, China.
Yifeng YaoState Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, China.
Jiamin LiuState Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, China.
Yanni TanState Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, China.ORCID 0000-0002-5453-5620
Qingge WangState Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, China.ORCID 0000-0001-9624-682X
Man FangState Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, China.
Aqsa KanwalState Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, China.
Shuqiao ChengDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, China.
Juan HuangDepartment of Breast Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Hong WuState Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, China.ORCID 0000-0002-8349-4944

Funding

Central South University Research Program of Advanced Interdisciplinary Studies 2023QYJC038National Natural Science Foundation of China 12374022Natural Science Foundation for Distinguished Young Scholars of Hunan Province 2023JJ10075Natural Science Foundation of Hunan Province 2024JJ9133Postgraduate Scientific Research Innovation Project of Hunan Province CX20240203Scientific and Technological Project of Yunnan Precious Metals Laboratory YPML-2023050247Yuelushan Center for Industrial Innovation 2024YCII0106
6 · The paper itself

Abstract

To address the dual clinical challenges of poor osseointegration and inadequate analgesia caused by postoperative infections in traditional titanium implants, this study proposes a multifunctional synergistic strategy based on metal-organic frameworks (MOFs). By integrating drug-controlled release and ionic microenvironment regulation, it constructs a titanium-based implant coating system with antibacterial and bone-regenerative properties. Ketoprofen, a drug with excellent analgesic properties, was loaded into MgCu-MOF74 powder, and the Ket@MgCu-MOF74 powder was successfully anchored onto the surface of the titanium alloy through dopamine-mediated adhesion. The maximum load of ketoprofen to MgCu-MOF74 is 18.55%, and it has a good controllable release effect. The results showed that MgCu-MOF74/Ti and Ket@MgCu-MOF74/Ti coatings enhanced osteogenic performance by promoting alkaline phosphatase activity, collagen secretion, and extracellular matrix mineralization. Additionally, the release of Mg

Indexed as

antibacterial propertymetal–organic frameworkosseointegrationsurface modificationtitanium alloy

Identifiers

PMID40558908
PMCPMC12194423

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.