Evidence map›Paper›PMID 40558797›Full record

ArticleJournal of imaging2025

Quantitative Ultrashort Echo Time Magnetization Transfer Imaging of the Osteochondral Junction: An In Vivo Knee Osteoarthritis Study.

Dina Moazamian, Mahyar Daskareh, Jiyo S Athertya, Arya A Suprana, Saeed Jerban, Yajun Ma

Abstract read
In one paragraph

Article in Journal of imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Advances in cartilage imaging techniques.Nature reviews. Rheumatology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dina MoazamianDepartment of Radiology, University of California, San Diego, CA 92037, USA.ORCID 0000-0002-8815-4535
Mahyar DaskarehDepartment of Radiology, University of California, San Diego, CA 92037, USA.ORCID 0000-0001-5601-6392
Jiyo S AthertyaDepartment of Radiology, University of California, San Diego, CA 92037, USA.ORCID 0000-0002-0866-1052
Arya A SupranaDepartment of Radiology, University of California, San Diego, CA 92037, USA.
Saeed JerbanDepartment of Radiology, University of California, San Diego, CA 92037, USA.ORCID 0000-0001-6450-2892
Yajun MaDepartment of Radiology, University of California, San Diego, CA 92037, USA.

Funding

Ultrashort Echo Time Magnetic Resonance Imaging of the Lumbar Intervertebral Disc.R01AR079484 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Yajun Ma · 2022 to 2026
$2.7M
Knee evaluation under mechanical loading by cones ultrashort echo time MR imagingK01AR080257 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI saeed jerban · 2022 to 2026
$602k
Comparison of direct and indirect magnetic resonance imaging of myelin in Alzheimer's diseaseF32AG082458 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ATHERTYA, JIYO S · 2023 to 2025
$256k
Jiyo S. Aterthya F32AG082458NIAMS NIH HHS K01 AR080257NIAMS NIH HHS R01 AR079484NIA NIH HHS F32 AG082458Saeed Jerban K01AR080257Yajun Ma R01AR079484
6 · The paper itself

Abstract

Osteoarthritis (OA) is the most prevalent degenerative joint disorder worldwide, causing significant declines in quality of life. The osteochondral junction (OCJ), a critical structural interface between deep cartilage and subchondral bone, plays an essential role in OA progression but is challenging to assess using conventional magnetic resonance imaging (MRI) due to its short T2 relaxation times. This study aimed to evaluate the utility of ultrashort echo time (UTE) MRI biomarkers, including macromolecular fraction (MMF), magnetization transfer ratio (MTR), and T2*, for in vivo quantification of OCJ changes in knee OA for the first time. Forty-five patients (mean age: 53.8 ± 17.0 years, 50% female) were imaged using 3D UTE-MRI sequences on a 3T clinical MRI scanner. Patients were stratified into two OA groups based on radiographic Kellgren-Lawrence (KL) scores: normal/subtle (KL = 0-1) (

Indexed as

macromolecular fraction (MMF)magnetization transfer ratio (MTR)osteoarthritis (OA)osteochondral junction (OCJ)ultrashort echo time (UTE) MRI

Identifiers

PMID40558797
PMCPMC12193826

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.