Evidence map›Paper›PMID 40558742›Full record

ArticleGels (Basel, Switzerland)2025

Synthesis of Temperature/pH Dual-Responsive Double-Crosslinked Hydrogel on Medical Titanium Alloy Surface.

Yutong Li, Jiaqi Wang, Shouxin Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yutong LiKey Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710119, China.
Jiaqi WangKey Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710119, China.
Shouxin LiuKey Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710119, China.ORCID 0000-0002-8368-5118

Funding

The National Natural Science Foundation of China 21773147The National Natural Science Foundation of China (No. 21773147) 21773147
6 · The paper itself

Abstract

Medical titanium alloy Ti-6Al-4V (TC4) is widely used as a surgical implant material in biomedical fields owing to its superior biocompatibility, corrosion resistance, and mechanical performance, particularly for osseous integration applications. However, long-term contact of medical titanium-based implants with human soft tissues may induce infection and inflammation. To address these limitations, a drug-loading gel was designed to be synthesized on a TC4 surface to improve biointegration. Considering the critical regulatory roles of temperature and pH in physiological environments, this study synthesized a dual-responsive hydrogel using the temperature-sensitive monomers 2-(2-methoxyethoxy)ethyl methacrylate (MEO

Indexed as

double crosslinkinghydrogelmedical titanium alloysustained drug releasetemperature/pH responsiveness

Identifiers

PMID40558742
PMCPMC12191475

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.