Evidence map›Paper›PMID 40558719›Full record

ReviewGels (Basel, Switzerland)2025

Advances in Composite Stimuli-Responsive Hydrogels for Wound Healing: Mechanisms and Applications.

Ke Ding, Mingrui Liao, Yingyu Wang, Jian R Lu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ke DingBiological Physics Group, Department of Physics and Astronomy, School of Natural Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
Mingrui LiaoBiological Physics Group, Department of Physics and Astronomy, School of Natural Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UK.ORCID 0000-0002-9481-4026
Yingyu WangBiological Physics Group, Department of Physics and Astronomy, School of Natural Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
Jian R LuBiological Physics Group, Department of Physics and Astronomy, School of Natural Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UK.ORCID 0000-0001-5648-3564

Funding

Biotechnology and Biological Sciences Research Council ST/Z510038/1Science and Technology Facilities Council ST/Y000552/1
6 · The paper itself

Abstract

Stimuli-responsive hydrogels have emerged as a promising class of biomaterials for advanced wound healing applications, offering dynamic and controllable responses to the wound microenvironment. These hydrogels are designed to respond to specific stimuli, such as pH, temperature, light, and enzyme activity, enabling precise regulation of drug release, antimicrobial activity, and tissue regeneration. Composite stimuli-responsive hydrogels, by integrating multiple response mechanisms and functions, show potential for addressing the diverse needs of wound healing. This review explores the biological mechanisms of wound healing, the design and classification of composite stimuli-responsive hydrogels, and the key fabrication strategies employed to optimise their properties. Despite their immense potential, unresolved challenges such as biocompatibility, long-term stability, and scalability continue to limit their translation into clinical practice. Future research will focus on integrating hydrogels with smart wearable devices, AI-driven personalised medicine, and 3D bioprinting technologies to develop next-generation wound care solutions. With continuous advancements in biomaterials science and bioengineering, stimuli-responsive hydrogels hold great promise for revolutionising wound management.

Indexed as

antibacterial hydrogelsbioactive agentsbiomedical applicationscomposite hydrogelscontrolled drug releasesmart biomaterialsstimuli-responsive hydrogelswound healing

Identifiers

PMID40558719
PMCPMC12191909

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.