Evidence map›Paper›PMID 40558625›Full record

ReviewEuropean burn journal2025

Laboratory-Generated Autologous Skin Substitutes for Burn Treatment in Europe: Narrative Review, Experts' Opinion, and Legal Considerations.

Celine Auxenfans, Rocio G Valencia, Philippe Abdel-Sayed, Miguel Alaminos, Jean-François Brunet, Fernando Campos, Jesus Chato-Astrain, Gloria Carmona, Anthony de Buys Roessingh, Stephanie Droz-Georget and 16 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European burn journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Celine AuxenfansBanque de Tissus et Cellules, Plateforme de Biotherapies, Hospices Civils de Lyon, 69002 Lyon, France.ORCID 0000-0001-8599-8479
Rocio G ValenciaPediatric Burn Center, Children's Skin Center, Department of Surgery, University Children's Hospital Zurich, University of Zurich, Lenggstrassse 30, 8008 Zurich, Switzerland.
Philippe Abdel-SayedRegenerative Therapy Unit, Service of Plastic, Reconstructive & Hand Surgery, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.ORCID 0000-0002-6054-0573
Miguel AlaminosTissue Engineering Group, Department of Histology, Instituto de Investigación Biosanitaria ibs.GRANADA, University of Granada, 18012 Granada, Spain.
Jean-François BrunetCell Production Center (CPC), Lausanne University Hospital (CHUV), 1005 Lausanne, Switzerland.ORCID 0000-0002-6384-9875
Fernando CamposTissue Engineering Group, Department of Histology, Instituto de Investigación Biosanitaria ibs.GRANADA, University of Granada, 18012 Granada, Spain.
Jesus Chato-AstrainTissue Engineering Group, Department of Histology, Instituto de Investigación Biosanitaria ibs.GRANADA, University of Granada, 18012 Granada, Spain.ORCID 0000-0002-2378-2696
Gloria CarmonaAndalusian Network for the Design and Translation of Advanced Therapies (AND&TAT)-Fundación Pública Andaluza Progreso y Salud, 41092 Sevilla, Spain.ORCID 0000-0001-9793-4755
Anthony de Buys RoessinghChildren and Adolescent Surgery Service, Lausanne University Hospital, University of Lausanne, 1015 Lausanne, Switzerland.ORCID 0000-0002-2174-4549
Stephanie Droz-GeorgetLaboratory of Stem Cell Dynamics, School of Life Sciences, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
Melinda FarkasPediatric Burn Center, Children's Skin Center, Department of Surgery, University Children's Hospital Zurich, University of Zurich, Lenggstrassse 30, 8008 Zurich, Switzerland.ORCID 0009-0007-1115-0089
Ana Fernandez GonzalezAndalusian Network for the Design and Translation of Advanced Therapies (AND&TAT)-Fundación Pública Andaluza Progreso y Salud, 41092 Sevilla, Spain.
Enikö GöncziPediatric Burn Center, Children's Skin Center, Department of Surgery, University Children's Hospital Zurich, University of Zurich, Lenggstrassse 30, 8008 Zurich, Switzerland.
Fredrik HussDepartment of Plastic and Maxillofacial Surgery, Department of Surgical Sciences, Uppsala University Hospital, 752 37 Uppsala, Sweden.ORCID 0000-0002-9735-1434
Bernd HartmannUnfallkrankenhaus Berlin, 12683 Berlin, Germany.
Barbara HeusiPediatric Burn Center, Children's Skin Center, Department of Surgery, University Children's Hospital Zurich, University of Zurich, Lenggstrassse 30, 8008 Zurich, Switzerland.
Alexandra KarströmDepartment of Plastic and Maxillofacial Surgery, Department of Surgical Sciences, Uppsala University Hospital, 752 37 Uppsala, Sweden.ORCID 0009-0008-9592-3129
Naiem MoiemenCollege of Medicine and Health, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.ORCID 0000-0003-0836-5138
Giulia SartorisPediatric Burn Center, Children's Skin Center, Department of Surgery, University Children's Hospital Zurich, University of Zurich, Lenggstrassse 30, 8008 Zurich, Switzerland.
Antje SprangerUnfallkrankenhaus Berlin, 12683 Berlin, Germany.
Marina TrouillasATMP Unit, French Armed-Forces Blood Transfusion Center, 92140 Clamart, France.
Claudia RosasPediatric Burn Center, Children's Skin Center, Department of Surgery, University Children's Hospital Zurich, University of Zurich, Lenggstrassse 30, 8008 Zurich, Switzerland.
Jyrki VuolaHelsinki Burn Centre, Helsinki University Hospital, University of Helsinki, P.O. Box 263, 00029 Helsinki, Finland.
Vivienne WoodtliPediatric Burn Center, Children's Skin Center, Department of Surgery, University Children's Hospital Zurich, University of Zurich, Lenggstrassse 30, 8008 Zurich, Switzerland.ORCID 0009-0003-2389-3817
Clemens SchiestlPediatric Burn Center, Children's Skin Center, Department of Surgery, University Children's Hospital Zurich, University of Zurich, Lenggstrassse 30, 8008 Zurich, Switzerland.
Sophie BöttcherPediatric Burn Center, Children's Skin Center, Department of Surgery, University Children's Hospital Zurich, University of Zurich, Lenggstrassse 30, 8008 Zurich, Switzerland.ORCID 0000-0002-7713-9807

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autologous skin substitutes represent a promising advancement in the treatment of burn injuries, offering personalized solutions for patients with extensive skin loss. This white paper synthesizes the current knowledge on laboratory-generated autologous skin substitutes in Europe, incorporating expert opinions and legal considerations. The white paper examines the scientific principles underlying autologous skin substitute development, including cell sourcing, bioengineering techniques, and clinical applications. The regulatory framework governing the production and use of these advanced therapies in Europe is also examined, highlighting challenges in standardization, safety, and approval pathways. The text features expert insights that offer a real-world perspective on the clinical viability and translational hurdles of autologous skin substitutes. The findings highlight the potential of autologous skin substitutes to improve burn treatment outcomes while emphasizing the need for harmonized regulations to facilitate clinical implementation. Despite technological advancements, significant challenges persist, including production costs, scalability, and long-term efficacy. Another focus of this white paper are the legal changes, which have significantly impacted the production and availability of these technologies. The review concludes that while autologous skin substitutes hold great promise, further research, regulatory refinement, and interdisciplinary collaboration are essential to optimize their integration into clinical practice.

Indexed as

autologous skin substituteburn treatmentlegal considerations

Identifiers

PMID40558625
PMCPMC12191448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.