Evidence map›Paper›PMID 40558592›Full record

ArticleDiseases (Basel, Switzerland)2025

A Potential Oncoprotective Role of Cytomegalovirus Against Breast Cancer: Worldwide Correlation and Survey of Evidence.

Marko Jankovic, Sofija Glumac, Aleksandra Knezevic, Ana Tomic, Danijela Miljanovic, Jovana Cupic, Ana Banko, Djurdjina Kablar, Ivana Celic, Sara Urosevic and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diseases (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marko JankovicDepartment of Virology, Institute of Microbiology and Immunology, 1 Dr Subotica Street, 11000 Belgrade, Serbia.ORCID 0000-0001-5993-0577
Sofija GlumacFaculty of Medicine, University of Belgrade, 8 Dr Subotica Street, 11000 Belgrade, Serbia.ORCID 0000-0002-2720-4148
Aleksandra KnezevicDepartment of Virology, Institute of Microbiology and Immunology, 1 Dr Subotica Street, 11000 Belgrade, Serbia.ORCID 0000-0003-3451-810X
Ana TomicCenter for Radiology Imaging, University Clinical Center of Serbia, 2 Pasterova Street, 11000 Belgrade, Serbia.ORCID 0009-0003-4212-0182
Danijela MiljanovicDepartment of Virology, Institute of Microbiology and Immunology, 1 Dr Subotica Street, 11000 Belgrade, Serbia.ORCID 0000-0001-9446-8701
Jovana CupicClinic for Gynecology and Obstetrics, University Clinical Center of Serbia, 11000 Belgrade, Serbia.ORCID 0000-0001-7378-3614
Ana BankoDepartment of Virology, Institute of Microbiology and Immunology, 1 Dr Subotica Street, 11000 Belgrade, Serbia.ORCID 0000-0002-6829-096X
Djurdjina KablarDepartment for Pathology, Pathohistology and Medical Cytology, University Clinical Centre of Serbia, 11000 Belgrade, Serbia.
Ivana CelicFaculty of Medicine, University of Belgrade, 8 Dr Subotica Street, 11000 Belgrade, Serbia.
Sara UrosevicFaculty of Medicine, University of Belgrade, 8 Dr Subotica Street, 11000 Belgrade, Serbia.
Ivana LazarevicDepartment of Virology, Institute of Microbiology and Immunology, 1 Dr Subotica Street, 11000 Belgrade, Serbia.ORCID 0000-0001-6795-1378

Funding

Ministry of Science, Technological Development and Innovation of the Republic of Serbia 451-03-66/2024-03/200110
6 · The paper itself

Abstract

introductionWhile not considered a genuine tumorigenic pathogen, the human cytomegalovirus (CMV) has been associated with a wide assortment of malignancies, including breast cancer (BC). In recent years, increasing evidence has been detailing the potential anti-oncogenic capabilities of CMV. Works in the literature addressing the issue are scarce, and a global approach elucidating the role of CMV in breast cancer is lacking.

aimWe inquired into the association between CMV and BC on a global level and surveyed the related literature. MATERIAL AND

methodsVirus-tumor interaction was examined by correlating country-specific CMV seroprevalence and the age-standardized BC incidence rates for 73 countries, as provided by the International Agency for Research on Cancer (IARC). Statistical analysis was conducted using Spearman's correlation, along with univariate and multivariate linear regression analysis. The literature review included works available in the PubMed

resultsThe worldwide incidence of BC correlated strongly and inversely with CMV prevalence the world over (

conclusionsIn this study, we draw attention to a previously unexplored global inverse relationship between the prevalence of CMV and the incidence of BC, which suggests a potential oncoprotective role for this pathogen. Although the association itself does not imply causality, these data provide an intriguing possibility of observing CMV as a tentative factor of protection against this malignancy.

Indexed as

breast cancercytomegalovirusoncoprotectionworldwide

Identifiers

PMID40558592
PMCPMC12191940

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.