Evidence map›Paper›PMID 40558540›Full record

ArticleCells2025

Downregulated

Zili Zhai, Takeshi Yamauchi, Karenna Sandoval, Kira Villarreal, Man Wai Charlotte Kwong, Emily J Swanson, Aik Choon Tan, Mayumi Fujita

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zili ZhaiDepartment of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0001-5164-3696
Takeshi YamauchiDepartment of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-7050-7531
Karenna SandovalDepartment of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0009-0008-0530-3437
Kira VillarrealDepartment of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Man Wai Charlotte KwongDepartment of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Emily J SwansonDepartment of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Aik Choon TanDepartment of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0003-2955-8369
Mayumi FujitaDepartment of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-1498-1925

Funding

Transgenic and Gene Targeting CoreP30AR057212 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI HOGAN, CHRISTOPHER J · 2009 to 2018
$6.2M
The role of IL-37 in human regulatory T cells, SupplementR01AI156534 · NIAID · UNIVERSITY OF COLORADO DENVER · PI FUJITA, MAYUMI · 2021 to 2025
$3.0M
Modulation of Inflammasome-mediated cytokine activation by EGCG in human melanomaR01CA197919 · NCI · UNIVERSITY OF COLORADO DENVER · PI FUJITA, MAYUMI · 2016 to 2020
$1.9M
Ethanol-induced skin changesR21AA028904 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI FUJITA, MAYUMI · 2021 to 2022
$408k
BLRD VA I01 BX001228BLRD VA I01 BX006598NCI NIH HHS R01 CA197919NIAAA NIH HHS R21 AA028904NIAID NIH HHS R01 AI156534NIAMS NIH HHS P30 AR057212NIH/NI- 480 AAA R21AA028904NIH/NIAID R01AI156534-01A1
6 · The paper itself

Abstract

Aldehyde dehydrogenase 2 (ALDH2) is a crucial detoxifying enzyme that eliminates toxic aldehydes. ALDH2 deficiency has been linked to various human diseases, including certain cancers. We have previously reported

Indexed as

Aldehyde Dehydrogenase, MitochondrialDisease ProgressionDown-RegulationDrug Resistance, NeoplasmMelanomaMolecular Targeted TherapyAnimalsCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansMAP Kinase Signaling SystemMiceNeoplasm MetastasisAldehyde Dehydrogenase, MitochondrialALDH2 protein, humanacetaldehydealdehyde dehydrogenase 2drug resistanceMAPK/ERKmelanomatargeted therapy

Identifiers

PMID40558540
PMCPMC12191128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.