Evidence map›Paper›PMID 40558531›Full record

ArticleCells2025

Prenatal Delta-9-Tetrahydrocannabinol Exposure Induces Transcriptional Alterations in Dopaminergic System with Associated Electrophysiological Dysregulation in the Prefrontal Cortex of Adolescent Rats.

Martina Di Bartolomeo, Sonia Aroni, Marcello Serra, Valeria Serra, Francesca Martella, Federica Gilardini, Miriam Melis, Claudio D'Addario

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Martina Di BartolomeoDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy.ORCID 0000-0003-4266-7607
Sonia AroniDepartment of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology, University of Cagliari, 09100 Cagliari, Italy.ORCID 0000-0001-6864-8784
Marcello SerraDepartment of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology, University of Cagliari, 09100 Cagliari, Italy.ORCID 0000-0003-4025-7233
Valeria SerraDepartment of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology, University of Cagliari, 09100 Cagliari, Italy.ORCID 0000-0003-1734-3029
Francesca MartellaDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy.ORCID 0009-0003-9921-8690
Federica GilardiniDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy.
Miriam MelisDepartment of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology, University of Cagliari, 09100 Cagliari, Italy.ORCID 0000-0001-9631-8651
Claudio D'AddarioDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy.ORCID 0000-0002-1275-098X

Funding

European Union - NextGenerationEU, Mission 4, Component 1, under the Italian Ministry of University and Research (MUR) National Innovation Ecosystem ECS00000041 - VITALITY - CUP: C43C22000380007Italian Minister of the University and Research FISR201900202-DIETAMIItalian Minister of the University and Research PRIN2022 2022K7YKTY
6 · The paper itself

Abstract

Prenatal cannabis exposure (PCE) has been associated with altered prefrontal cortex (PFC) activity and connectivity in adulthood, potentially increasing the risk of psychopathology later in life. This risk is thought to involve a complex interplay between the endocannabinoid and dopaminergic systems. We investigated the transcriptional regulation of genes associated with these systems in an animal model of PCE during adolescence, focusing on DNA methylation and specific microRNAs (miRNAs). Our study revealed increased mRNA levels of dopamine D1 and D2 receptors (

Indexed as

DopamineDopaminergic NeuronsDronabinolElectrophysiological PhenomenaPrefrontal CortexPrenatal Exposure Delayed EffectsTranscription, GeneticAnimalsDNA MethylationFemaleMaleMicroRNAsPregnancyRatsReceptors, Dopamine D1Receptors, Dopamine D2DopamineDronabinolMicroRNAsReceptors, Dopamine D1Receptors, Dopamine D2DNA methylationdopamine D1 receptordopamine D2 receptorelectrophysiologymiRNAsNetrin-1sexTHC

Identifiers

PMID40558531
PMCPMC12191062

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.