Evidence map›Paper›PMID 40558523›Full record

ArticleCells2025

Alterations of JNK Signaling Pathway Activity in the Rat Retina: Effects of Age, Age-Related Macular Degeneration-like Pathology, and a JNK Inhibitor (IQ-1S).

Natalia A Muraleva, Dmitry I Tikhonov, Anna A Zhdankina, Mark B Plotnikov, Andrei I Khlebnikov, Sergey V Logvinov, Nataliya G Kolosova

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In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Chemistry and Biological Activity of 11Molecules (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Natalia A MuralevaFederal Research Center Institute of Cytology and Genetics SB RAS, 10 Pr. Akad. Lavrentieva, Novosibirsk 630090, Russia.ORCID 0000-0002-0665-1723
Dmitry I TikhonovDepartment of Histology, Embryology and Cytology, Siberian State Medical University, Tomsk 634055, Russia.
Anna A ZhdankinaDepartment of Histology, Embryology and Cytology, Siberian State Medical University, Tomsk 634055, Russia.ORCID 0000-0002-4954-7416
Mark B PlotnikovDepartment of Pharmacology, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk NRMC, 3 Lenin Ave., Tomsk 634028, Russia.ORCID 0000-0002-0548-6586
Andrei I KhlebnikovKizhner Research Center, Tomsk Polytechnic University, 30 Lenin Ave, Tomsk 634050, Russia.ORCID 0000-0002-3022-4510
Sergey V LogvinovDepartment of Histology, Embryology and Cytology, Siberian State Medical University, Tomsk 634055, Russia.
Nataliya G KolosovaFederal Research Center Institute of Cytology and Genetics SB RAS, 10 Pr. Akad. Lavrentieva, Novosibirsk 630090, Russia.ORCID 0000-0003-2398-8544

Funding

Russian Science Foundation 24-25-00030
6 · The paper itself

Abstract

Age-related macular degeneration (AMD) is the leading cause of irreversible visual impairment worldwide. AMD development is associated with inflammation, oxidative stress, and a progressive proteostasis imbalance, in whose regulation, c-Jun N-terminal kinases (JNKs) play a crucial role. JNK inhibition is being discussed as a new way to prevent and treat AMD, but there are no data on JNK signaling in the retina and its changes with age and with AMD development. Here, for the first time, we assessed JNK-signaling activity in the retina and did not detect its age-related changes in healthy Wistar rats. By contrast, manifestation and progression of the AMD-like pathology in OXYS rats occurred simultaneously with JNK pathway activation. We also confirmed that selective JNK3 inhibitor 11H-indeno[1,2-b]quinoxalin-11-one oxime sodium salt (IQ-1S) can suppress neurodegenerative changes in the OXYS rat retina. Its effects were prevention of the destructive changes in retinal synapses and the suppression of the JNK signaling pathway activity during active progression of AMD signs in OXYS rats.

Indexed as

AgingMacular DegenerationMAP Kinase Signaling SystemOximesProtein Kinase InhibitorsQuinoxalinesRetinaAnimalsDisease Models, AnimalMaleRatsRats, WistarOximesProtein Kinase InhibitorsQuinoxalinesageage-related macular degenerationIQ-1SJNK inhibitorJNK signalingOXYS ratsretinasynapses

Identifiers

PMID40558523
PMCPMC12190811

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.