Evidence map›Paper›PMID 40558521›Full record

ArticleCells2025

Mitogen-Activated Protein Kinase Kinase Kinase 1 Overexpression Disrupts Development of the Ocular Surface Epithelium.

Maureen Mongan, Bo Xiao, Antonius Christianto, Yueh-Chiang Hu, Ying Xia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maureen MonganDepartment of Environmental and Public Health Sciences, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Bo XiaoDepartment of Environmental and Public Health Sciences, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Antonius ChristiantoDepartment of Environmental and Public Health Sciences, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Yueh-Chiang HuDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45267, USA.ORCID 0000-0002-7992-0525
Ying XiaDepartment of Environmental and Public Health Sciences, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.ORCID 0000-0001-9532-9527

Funding

Gene-environment interactions in epithelial morphogenesisR01HD098106 · NICHD · UNIVERSITY OF CINCINNATI · PI XIA, YING · 2019 to 2023
$2.3M
Signaling mechanisms of gene-environment interactions in female reproductiveR21ES033342 · NIEHS · UNIVERSITY OF CINCINNATI · PI XIA, YING · 2022 to 2023
$446k
National Institute of Health, USA RO1 HD098106, R21 ES033342NICHD NIH HHS R01 HD098106NIEHS NIH HHS R21 ES033342
6 · The paper itself

Abstract

Mitogen-Activated Protein Kinase Kinase Kinase 1 (MAP3K1) is a key signaling molecule essential for eyelid closure during embryogenesis. In mice,

Indexed as

MAP Kinase Kinase Kinase 1AnimalsCell DifferentiationEpithelial CellsEpitheliumEyelidsLens, CrystallineMiceMice, KnockoutMice, TransgenicMap3k1 protein, mouseMAP Kinase Kinase Kinase 1epithelial morphogenesiseyelid closureMAP3K1 gain-of-functionocular surface epithelium

Identifiers

PMID40558521
PMCPMC12190364

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.