Evidence map›Paper›PMID 40558489›Full record

ReviewCells2025

NAA10 (N-Alpha-Acetyltransferase 10): A Multifunctional Regulator in Development, Disease, and Cancer.

Zeng Quan Yang, Ion John Campeanu, Ivan Lopez, Manaal Syed, Yuanyuan Jiang, Hilda Afisllari

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zeng Quan YangMolecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, USA.
Ion John CampeanuDepartment of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Ivan LopezDepartment of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Manaal SyedDepartment of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Yuanyuan JiangDepartment of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Hilda AfisllariDepartment of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA.ORCID 0009-0003-4909-9224

Funding

Department of Defense (DoD) Breast Cancer Program BC201476DMC Foundation G-202219935DoD Peer Reviewed Cancer Research Program HT94252310620
6 · The paper itself

Abstract

NAA10 (N-alpha-acetyltransferase 10) is a pivotal enzyme in eukaryotic cells, serving as the catalytic subunit of the NatA complex, which is responsible for the N-terminal acetylation of approximately 40-50% of the human proteome. Beyond its canonical role in co-translational N-terminal acetylation, NAA10 also acetylates internal lysine residues of various proteins and exerts non-catalytic regulatory functions through diverse protein-protein interactions. Pathogenic variants in

Indexed as

NeoplasmsN-Terminal Acetyltransferase AN-Terminal Acetyltransferase EAnimalsHumansNAA10 protein, humanN-Terminal Acetyltransferase AN-Terminal Acetyltransferase Eacetyltransferasecancerdevelopmental disorderNAA10N-terminal acetylation

Identifiers

PMID40558489
PMCPMC12190189

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.