Evidence map›Paper›PMID 40558470›Full record

ArticleBiosensors2025

Parylene-C Modified OSTE Molds for PDMS Microfluidic Chip Fabrication and Applications in Plasma Separation and Polymorphic Crystallization.

Muyang Zhang, Haonan Li, Xionghui Li, Zitong Ye, Qinghao He, Jie Zhou, Jiahua Zhong, Hao Chen, Xinyi Chen, Yixi Shi and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Muyang ZhangMOE Key Laboratory of Tumor Molecular Biology, Jinan University, Guangzhou 510632, China.
Haonan LiDepartment of Biomedical Engineering, Shantou University, Shantou 515063, China.ORCID 0009-0004-1982-8710
Xionghui LiDepartment of Biomedical Engineering, Shantou University, Shantou 515063, China.ORCID 0009-0007-3737-5411
Zitong YeDepartment of Biomedical Engineering, Shantou University, Shantou 515063, China.
Qinghao HeDepartment of Biomedical Engineering, Shantou University, Shantou 515063, China.
Jie ZhouDepartment of Biomedical Engineering, Shantou University, Shantou 515063, China.
Jiahua ZhongDepartment of Biomedical Engineering, Shantou University, Shantou 515063, China.
Hao ChenDepartment of Biomedical Engineering, Shantou University, Shantou 515063, China.
Xinyi ChenDepartment of Biomedical Engineering, Shantou University, Shantou 515063, China.ORCID 0009-0005-0816-9091
Yixi ShiDepartment of Biomedical Engineering, Shantou University, Shantou 515063, China.
Huiru ZhangGuangdong Foshan Lianchuang Graduate School of Engineering, Foshan 528311, China.
Lok Ting ChuInstitute of Biochemistry and Molecular Biology, Guangdong Medical University, Zhanjiang 524023, China.
Weijin GuoDepartment of Biomedical Engineering, Shantou University, Shantou 515063, China.ORCID 0000-0003-2444-6771

Funding

Bureau of Education of Foshan City 2024SWYY03Bureau of Education of Foshan City 2024SWYY04Department of Education of Guangdong Province 2022KQNCX019Department of Education of Guangdong Province 2024KQNCX107Guangdong Basic and Applied Basic Research Foundation 2022A1515110855Guangdong Medical University 4SG24241GNational Excellent Engineer Innovation Research Institute for Advanced Manufacturing Industry in Guangdong Hong Kong Macao Greater Bay Area (Foshan) 2023FCXM016National Natural Science Foundation of China 62341403National Natural Science Foundation of China 62404130Shantou University NTF20034
6 · The paper itself

Abstract

This work presents a novel microfabrication process that addresses the interference of thiol groups on off-stoichiometry thiolene (OSTE) surfaces with the curing of polydimethylsiloxane (PDMS) by integrating the high-performance polymer Parylene-C. The process utilizes a Parylene-C coating to encapsulate the active thiol groups on the OSTE surface, enabling precise replication of PDMS microstructures. Based on this method, PDMS micropillar arrays and microwell arrays were successfully fabricated and applied in passive plasma separation and polymorphic crystal formation, respectively. The experimental results demonstrate that the plasma-separation chip efficiently isolates plasma from whole-blood samples with varying hematocrit (HCT) levels, achieving a separation efficiency of up to 57.5%. Additionally, the microwell array chip exhibits excellent stability and controllability in the growth of salt and protein crystals. This study not only provides a new approach for microfabricating microfluidic chips, but also highlights its potential applications in biomedical diagnostics and materials science.

Indexed as

DimethylpolysiloxanesLab-On-A-Chip DevicesMicrofluidic Analytical TechniquesPlasmaPolymersXylenesBiosensing TechniquesCrystallizationHumansbaysilonDimethylpolysiloxanesparylenePolymersXylenesmicrofluidic chipOSTEparylene-Cplasma separationpolymorphic crystallization

Identifiers

PMID40558470
PMCPMC12191429

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.