Evidence map›Paper›PMID 40558468›Full record

ArticleBiosensors2025

A High-Sensitivity, Bluetooth-Enabled PCB Biosensor for HER2 and CA15-3 Protein Detection in Saliva: A Rapid, Non-Invasive Approach to Breast Cancer Screening.

Hsiao-Hsuan Wan, Chao-Ching Chiang, Fan Ren, Cheng-Tse Tsai, Yu-Siang Chou, Chun-Wei Chiu, Yu-Te Liao, Dan Neal, Coy D Heldermon, Mateus G Rocha and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hsiao-Hsuan WanDepartment of Chemical Engineering, University of Florida, Gainesville, FL 32611, USA.ORCID 0000-0002-6986-8217
Chao-Ching ChiangDepartment of Chemical Engineering, University of Florida, Gainesville, FL 32611, USA.ORCID 0000-0002-0447-8170
Fan RenDepartment of Chemical Engineering, University of Florida, Gainesville, FL 32611, USA.ORCID 0000-0001-9234-019X
Cheng-Tse TsaiDepartment of Electronics and Electrical Engineering, National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan.
Yu-Siang ChouDepartment of Electronics and Electrical Engineering, National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan.
Chun-Wei ChiuDepartment of Electronics and Electrical Engineering, National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan.
Yu-Te LiaoDepartment of Electronics and Electrical Engineering, National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan.
Dan NealDepartment of Surgery, University of Florida, Gainesville, FL 32611, USA.
Coy D HeldermonDepartment of Medicine, Division of Hematology and Oncology, University of Florida, Gainesville, FL 32611, USA.ORCID 0000-0002-2148-2868
Mateus G RochaDepartment of Restorative Dental Science, Division of Prosthodontics, University of Florida, Gainesville, FL 32611, USA.ORCID 0000-0001-5658-5640
Josephine F Esquivel-UpshawDepartment of Restorative Dental Science, Division of Prosthodontics, University of Florida, Gainesville, FL 32611, USA.ORCID 0000-0003-3642-8087

Funding

Novel coated nanostructured implant surfaces to increase osseointegration and decrease peri-implantitis in a physiologic rat modelR56DE025001 · NIDCR · UNIVERSITY OF FLORIDA · PI ESQUIVEL-UPSHAW, JOSEPHINE F. · 2022 to 2022
$650k
National Science and Technology Council, Taiwan NSTC 112-2628-E-A49-015NIDCR NIH HHS R56 DE025001NIH HHS 1R56DE025001-26A1University of Florida College of Dentistry Faculty Seed Grant 00132328
6 · The paper itself

Abstract

Breast cancer is a leading cause of cancer-related mortality worldwide, requiring efficient diagnostic tools for early detection and monitoring. Human epidermal growth factor receptor 2 (HER2) is a key biomarker for breast cancer classification, typically assessed using immunohistochemistry (IHC). However, IHC requires invasive biopsies and time-intensive laboratory procedures. In this study, we present a biosensor integrated with a reusable printed circuit board (PCB) and functionalized glucose test strips designed for rapid and non-invasive HER2 detection in saliva. The biosensor achieved a limit of detection of 10

Indexed as

Biosensing TechniquesBreast NeoplasmsErb-b2 Receptor Tyrosine KinasesMucin-1SalivaBiomarkers, TumorEarly Detection of CancerFemaleHumansLimit of DetectionBiomarkers, TumorERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesMUC1 protein, humanMucin-1biomarkerbiosensorbreast cancerCA15-3HER2high sensitivitynon-invasiveprinted circuit boardsalivascreening

Identifiers

PMID40558468
PMCPMC12190843

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.