Evidence map›Paper›PMID 40558459›Full record

ArticleBiosensors2025

Simple Nanochannel-Modified Electrode for Sensitive Detection of Alkaline Phosphatase Through Electrochemiluminescence Signal Quenching by Enzymatic Reaction.

Tianjun Ma, Xuan Luo, Fengna Xi, Nuo Yang

Abstract read
In one paragraph

Article in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Self-cascade Mn-FeMikrochimica acta · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tianjun MaThe First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Xuan LuoSchool of Chemistry and Chemical Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Fengna XiSchool of Chemistry and Chemical Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China.ORCID 0000-0001-8564-8911
Nuo YangThe First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.

Funding

National Natural Science Foundation of China 22374130the Joint Project on Regional High-Incidence Diseases Research of Guangxi Natural Science Foundation 2023JJB140332
6 · The paper itself

Abstract

Development of sensitive and convenient alkaline phosphatase (ALP) detection methods is of great significance for food analysis, biomedical applications, and clinical tests. In this work, a sensitive detection method for ALP was established based on nanochannel-modified electrodes, where the electrochemical luminescence (ECL) signal was quenched by the enzymatic reaction product. Vertically ordered mesoporous silica film (VMSF) was rapidly grown on low-cost ITO via the electrochemically assisted self-assembly (EASA) method. The resulting modified electrode (VMSF/ITO) exhibited a uniform and ordered nanochannel structure with nanochannel diameter of 2-3 nm and charge-selective permeability, enabling the enrichment of cationic ECL emitter tris(2,2'-bipyridyl)ruthenium(II) (Ru(bpy)

Indexed as

Alkaline PhosphataseBiosensing TechniquesElectrochemical TechniquesElectrodesLuminescent MeasurementsSilicon DioxideAlkaline PhosphataseSilicon Dioxidealkaline phosphataseelectrochemiluminescencehomogeneous sensingnanochannel-modified electrodesignal quenching

Identifiers

PMID40558459
PMCPMC12190674

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.