Evidence map›Paper›PMID 40558457›Full record

ReviewBiosensors2025

Advances of Nanozyme-Driven Multimodal Sensing Strategies in Point-of-Care Testing.

Ziyi Chang, Qingjie Fu, Mengke Wang, Demin Duan

Abstract readReview
In one paragraph

Review in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Sulfur-modified VRSC advances · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Peroxidase-Mimicking Nanozymes for Rapid Detection of Infectious Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ziyi ChangGraduate School of Xinxiang Medical University, Xinxiang 453003, China.
Qingjie FuNanozyme Laboratory in Zhongyuan, Henan Academy of Innovations in Medical Science, Zhengzhou 451163, China.
Mengke WangNanozyme Laboratory in Zhongyuan, Henan Academy of Innovations in Medical Science, Zhengzhou 451163, China.
Demin DuanNanozyme Laboratory in Zhongyuan, Henan Academy of Innovations in Medical Science, Zhengzhou 451163, China.ORCID 0000-0002-4461-697X

Funding

Key Program of Nanozyme Laboratory in Zhongyuan NLZ-KP2024NIC05National Natural Science Foundation of China No. 32371527
6 · The paper itself

Abstract

Point-of-care testing (POCT) has garnered widespread attention due to its rapid, convenient, and efficient detection capabilities, particularly playing an increasingly pivotal role in medical diagnostics and significantly improving the efficiency and quality of healthcare services. Nanozymes, as novel enzyme-mimicking materials, have emerged as a research hotspot owing to their superior catalytic performance, low cost, and robust stability. This review provides a systematic overview of the fundamental characteristics and classifications of nanozymes, along with various sensing strategies employed in POCT applications, colorimetric, electrochemical, fluorescent, chemiluminescent, and surface-enhanced Raman scattering (SERS)-based approaches. Furthermore, this review highlights innovative designs that enhance the sensitivity and accuracy of POCT across multiple domains, such as biomarker detection, environmental monitoring, and food safety analysis, thereby offering novel perspectives for the practical implementation of nanozymes in point-of-care diagnostics. Finally, this review analyzes current challenges in nanozyme-based POCT systems, including limitations in optimizing catalytic activity, ensuring nanozyme homogeneity, and achieving large-scale production, while proposing future development trajectories.

Indexed as

Biosensing TechniquesPoint-of-Care TestingCatalysisColorimetryElectrochemical TechniquesHumansPoint-of-Care SystemsSpectrum Analysis, Ramanbiomarker detectionnanozymesPOCTsensing strategies

Identifiers

PMID40558457
PMCPMC12190383

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.