Topology-Dependent Antifreeze Properties of Biomimetic Linear and Star-Shaped Peptoids.

Lei Feng, Liugen Xu, Junhao Wen, Minghai Zhao, Amjad Ali, Naushad Ahmad, Jianwei Lu, Li Guo

Abstract read

In one paragraph

Article in Biomimetics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lei FengSchool of Materials Sciences and Engineering, Jiangsu University, Zhenjiang 212013, China.ORCID 0009-0001-5172-4434

Liugen XuSchool of Materials Sciences and Engineering, Jiangsu University, Zhenjiang 212013, China.

Junhao WenSchool of Materials Sciences and Engineering, Jiangsu University, Zhenjiang 212013, China.

Minghai ZhaoSchool of Materials Sciences and Engineering, Jiangsu University, Zhenjiang 212013, China.

Amjad AliCollege of Materials Science and Engineering, Nanjing Forestry University, Nanjing 210037, China.ORCID 0000-0001-7112-4922

Naushad AhmadDepartment of Chemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-2913-1763

Jianwei LuSchool of Materials Sciences and Engineering, Jiangsu University, Zhenjiang 212013, China.ORCID 0000-0003-4189-0671

Li GuoSchool of Materials Sciences and Engineering, Jiangsu University, Zhenjiang 212013, China.ORCID 0000-0001-7427-8994

Funding

National Natural Science Foundation of China 51803081Researchers Supporting Project Number, King Saud University, Riyadh, Saudi Arabia RSPD2025R668

6 · The paper itself

Abstract

Developing safe and efficient cryoprotectants is critical for effective cryopreservation in biomedical applications. Inspired by natural antifreeze proteins (AFPs), a series of linear and star-shaped peptoids featuring isopropanol side chains to mimic the amphiphilic characteristics of threonine were prepared. The effects of chain length and molecular topology on antifreeze properties were systematically investigated. Both ice recrystallization inhibition (IRI) and ice crystal growth suppression improved with increasing chain length, and star-shaped peptoids exhibited superior performance. Notably, the star-shaped peptoid S-(A

Indexed as

antifreeze propertiescryopreservationstar-shaped peptoid

Identifiers

PMID40558337

DOI10.3390/biomimetics10060368

PMCPMC12190692

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.