Evidence map›Paper›PMID 40558288›Full record

ArticleCurrent oncology (Toronto, Ont.)2025

Population-Based Real-World Outcomes of Post-Operative Adjuvant Brain Cavity Radiotherapy Versus Observation.

Zhang Hao Jim Li, Linden Lechner, Jennifer Wang, Nan Hui Susan Yao, Andrew Lee, Serge Makarenko, Mostafa Fatehi, Herve H F Choi, Ermias Gete, Fred Hsu and 8 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Current oncology (Toronto, Ont.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Zhang Hao Jim LiDivision of Radiation Oncology, Department of Surgery, University of British Columbia, Vancouver, BC V5Z 4E6, Canada.ORCID 0000-0002-9174-048X
Linden LechnerFaculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.ORCID 0009-0008-9337-8542
Jennifer WangFaculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.ORCID 0009-0001-1026-2886
Nan Hui Susan YaoFaculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Andrew LeeDivision of Neurosurgery, Department of Surgery, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.
Serge MakarenkoDivision of Neurosurgery, Department of Surgery, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.
Mostafa FatehiDivision of Neurosurgery, Department of Surgery, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.
Herve H F ChoiDivision of Radiation Oncology, Department of Surgery, University of British Columbia, Vancouver, BC V5Z 4E6, Canada.ORCID 0009-0000-4226-3210
Ermias GeteDivision of Radiation Oncology, Department of Surgery, University of British Columbia, Vancouver, BC V5Z 4E6, Canada.
Fred HsuDivision of Radiation Oncology, Department of Surgery, University of British Columbia, Vancouver, BC V5Z 4E6, Canada.
Waseem SharieffDivision of Radiation Oncology, Department of Surgery, University of British Columbia, Vancouver, BC V5Z 4E6, Canada.ORCID 0009-0004-3906-9352
Shrinivas RathodDivision of Radiation Oncology, Department of Surgery, University of British Columbia, Vancouver, BC V5Z 4E6, Canada.
Hannah CarolanDivision of Radiation Oncology, Department of Surgery, University of British Columbia, Vancouver, BC V5Z 4E6, Canada.
Jessica ChanDivision of Radiation Oncology, Department of Surgery, University of British Columbia, Vancouver, BC V5Z 4E6, Canada.ORCID 0000-0002-5871-8221
Roy MaDivision of Radiation Oncology, Department of Surgery, University of British Columbia, Vancouver, BC V5Z 4E6, Canada.
Alan NicholDivision of Radiation Oncology, Department of Surgery, University of British Columbia, Vancouver, BC V5Z 4E6, Canada.ORCID 0000-0002-4146-881X
Thi NghiemData and Analytics, BC Cancer Agency, Vancouver, BC V5Z 4E6, Canada.
Justin OhDivision of Radiation Oncology, Department of Surgery, University of British Columbia, Vancouver, BC V5Z 4E6, Canada.ORCID 0000-0002-0921-8984

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To evaluate the factors influencing the outcomes of patients who underwent surgical resection of brain metastasis followed by either surveillance or post-operative stereotactic radiosurgery/fractionated radiotherapy (SRS/SFRT), a retrospective multi-center chart review was performed on all patients who underwent brain metastases resection in British Columbia between 2018 and 2020. Patients with prior whole-brain radiotherapy were excluded from the study. The primary study endpoints included local recurrence, distant intracranial control, radionecrosis (RN), leptomeningeal disease (LMD), and overall survival (OS). The Kaplan-Meier method was used to analyze survival. The Cox proportional hazards model was used to perform univariable (UVA) and multivariable (MVA) analyses to identify predictors of local control. A total of 113 patients met the inclusion criteria. A total of 31 patients received adjuvant SRS/SFRT to the surgical cavity, while 82 went on observation. The 12-month local control was 69% (50-88%) for the SRS/SFRT cohort and 31% (18-45%) for the observation cohort (

Indexed as

Brain NeoplasmsAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedRadiosurgeryRadiotherapy, AdjuvantRetrospective StudiesTreatment OutcomeCNS metastasisleptomeningeal diseasepalliative radiotherapyradionecrosisstereotactic radiosurgerystereotactic radiotherapy

Identifiers

PMID40558288
PMCPMC12191877

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.