Mechanisms and Functions of γδ T Cells in Tumor Cell Recognition.

Jing Tang, Chen Wu, Jintong Na, Yamin Deng, Simin Qin, Liping Zhong, Yongxiang Zhao

Abstract readReview

In one paragraph

Review in Current oncology (Toronto, Ont.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jing TangState Key Laboratory of Targeting Oncology, National Center for International Research of Bio-Targeting Therangstics, Guangxi Key Laboratory of Bio-Targeting Therangstics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Major New Drugs Innovation and Development, Guangxi Medical University, Nanning 530021, China.

Chen WuState Key Laboratory of Targeting Oncology, National Center for International Research of Bio-Targeting Therangstics, Guangxi Key Laboratory of Bio-Targeting Therangstics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Major New Drugs Innovation and Development, Guangxi Medical University, Nanning 530021, China.

Jintong NaState Key Laboratory of Targeting Oncology, National Center for International Research of Bio-Targeting Therangstics, Guangxi Key Laboratory of Bio-Targeting Therangstics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Major New Drugs Innovation and Development, Guangxi Medical University, Nanning 530021, China.

Yamin DengState Key Laboratory of Targeting Oncology, National Center for International Research of Bio-Targeting Therangstics, Guangxi Key Laboratory of Bio-Targeting Therangstics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Major New Drugs Innovation and Development, Guangxi Medical University, Nanning 530021, China.

Simin QinState Key Laboratory of Targeting Oncology, National Center for International Research of Bio-Targeting Therangstics, Guangxi Key Laboratory of Bio-Targeting Therangstics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Major New Drugs Innovation and Development, Guangxi Medical University, Nanning 530021, China.

Liping ZhongState Key Laboratory of Targeting Oncology, National Center for International Research of Bio-Targeting Therangstics, Guangxi Key Laboratory of Bio-Targeting Therangstics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Major New Drugs Innovation and Development, Guangxi Medical University, Nanning 530021, China.ORCID 0000-0002-8624-3091

Yongxiang ZhaoState Key Laboratory of Targeting Oncology, National Center for International Research of Bio-Targeting Therangstics, Guangxi Key Laboratory of Bio-Targeting Therangstics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Major New Drugs Innovation and Development, Guangxi Medical University, Nanning 530021, China.

Funding

Guangxi Natural Science Funds for Distinguished Young Scholars No. 2021JJG140008Guangxi Science and Technology Program No. 2022AB15002the Scientific and Technological Innovation Major Base of Guangxi No. 2022-36-Z05the Special Funds of the National Natural Science Foundation of China No. 82350106

6 · The paper itself

Abstract

γδ T cells are among the first line of defense in the immune system, playing a crucial role in bridging innate and adaptive immunity. Although γδ T cells are crucial for tumor immune surveillance, the complete mechanism by which γδ T cell receptors identify molecular targets in target cells remains unknown. Target cells can produce phosphoantigens (PAgs) via the mevalonate pathway or the methylerythritol phosphate pathway. The BTN3A1-BTN2A1 complex undergoes conformational changes in its extracellular domains upon binding to PAgs, leading to Vγ9Vδ2 T cell recognition. However, the structural basis of how Vγ9Vδ2 T cells recognize changes in this complex remains elusive. This review provides a detailed overview of the historical progress and recent discoveries regarding how Vγ9Vδ2 T cells recognize and target tumor cells. We also discuss the potential of γδ T cells immunotherapy and their role as antitumor agents.

Indexed as

NeoplasmsReceptors, Antigen, T-Cell, gamma-deltaT-LymphocytesAnimalsHumansImmunotherapyReceptors, Antigen, T-Cell, gamma-deltaadoptive therapyBTN3A1phosphoantigentumor cellγδ T cells

Identifiers

PMID40558272

DOI10.3390/curroncol32060329

PMCPMC12192272

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.