Evidence map›Paper›PMID 40558261›Full record

Trial reportCurrent oncology (Toronto, Ont.)2025

The Design of a Patient-Centered Hierarchal Composite Outcome for a Multi-Center Randomized Controlled Trial in Metastatic Bone Disease.

Hadia Farrukh, Abbey Kunzli, Olivia Virag, Nathan O'Hara, Sheila Sprague, Amy Cizik, Ricardo Gehrke-Becker, Thomas Schubert, Michelle Ghert

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Current oncology (Toronto, Ont.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hadia FarrukhDepartment of Surgery, McMaster University, Hamilton, ON L8S 4K1, Canada.ORCID 0009-0002-3826-8689
Abbey KunzliDepartment of Surgery, McMaster University, Hamilton, ON L8S 4K1, Canada.ORCID 0009-0008-7359-2496
Olivia ViragDepartment of Surgery, McMaster University, Hamilton, ON L8S 4K1, Canada.ORCID 0009-0003-0194-6105
Nathan O'HaraDepartment of Orthopaedics, University of Maryland, Baltimore, MD 21201, USA.
Sheila SpragueDepartment of Surgery, McMaster University, Hamilton, ON L8S 4K1, Canada.ORCID 0000-0003-1466-8063
Amy CizikDepartment of Orthopaedics, University of Utah, Salt Lake City, UT 84108, USA.ORCID 0000-0003-4777-2617
Ricardo Gehrke-BeckerHospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, Brazil.ORCID 0000-0003-2629-9752
Thomas SchubertDepartment of Orthopedic Surgery, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium.
Michelle GhertDepartment of Surgery, McMaster University, Hamilton, ON L8S 4K1, Canada.ORCID 0000-0002-4778-4522

Funding

A Planning Grant for a Multicenter Randomized Clinical Trial Comparing Hip Arthroplasty to Internal Fixation for Minimally Displaced Femoral Neck FracturesR34AR082550 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI O'HARA, NATHAN NOEL, SLOBOGEAN, GERARD · 2023 to 2024
$339k
A Planning Grant for a Multi-Center Randomized Controlled Trial Comparing Resection and Endoprosthetic Reconstruction vs. Internal Fixation for Metastatic Bone Disease of the Proximal FemurR34AR084146 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI GHERT, MICHELLE, O'HARA, NATHAN NOEL · 2024 to 2025
$297k
NIAMS NIH HHS R34 AR082550NIAMS NIH HHS R34 AR084146NIH HHS 1R34AR084146-01A1
6 · The paper itself

Abstract

The proximal femur represents the most frequent site in the appendicular skeleton for metastatic bone disease (MBD) to occur, with a high risk for pathologic fracture. While surgical stabilization is typically used to manage fractures, reconstruction approaches are gaining popularity due to improved survival. Previous studies have focused on clinical outcomes, but patient-centered outcomes remain underexplored. This study aims to develop a patient-centered primary outcome for the Proximal FEmur Reconstruction or Internal Fixation fOR Metastases (PERFORM) Randomized Controlled Trial, employing a mixed-methods approach. First, a focus group with advanced cancer patients and caregivers identified relevant outcomes. Next, a discrete choice experiment (DCE) assessed the importance of these outcomes among stakeholders, including surgeons, patients and caregivers. The most important components for the primary outcome were identified: mortality within twelve months, physical function assessed at four months using the PROMIS

Indexed as

Bone NeoplasmsFemaleHumansMalePatient-Centered CareRandomized Controlled Trials as Topicinternal fixationmetastatic bone diseaseproximal femurrandomized controlled trialreconstructionresection

Identifiers

PMID40558261
PMCPMC12191994

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.